FIGURE

Fig. 4

ID

ZDB-FIG-120316-92

Publication

Trofka et al., 2012 - The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub

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Fig. 4

Sensitivity analysis of the dimer network. (A) Schematic of Her dimer network. DNA-binding dimers are connected in red, non-DNA-binding dimers are connected in white. Networks present in the anterior or posterior PSM are segregated and indicated on the wild-type expression of her1. Weak dimers are connected by dashed lines. (B) Summary of local sensitivity analysis of posterior PSM Her/Hes network. Input parameters (total protein concentration and K_d) are listed along the bottom and output variables (Her monomer and dimer concentrations) along the left. Sensitivity values were calculated as the fractional change in each output variable (y) for a given fractional change in the corresponding input parameter (x), to give (Δy/y)/(Δx/x), averaged across 1000 randomly sampled parameter values. Red values indicate a positive relationship, whereas blue values indicate a negative relationship between changes in parameter value and effects on Her concentration. For example, a 1% increase in total Hes6 concentration decreases Her7/Her15 by 0.56%.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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