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Fig. 2

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ZDB-FIG-120202-4

Publication

Ulitsky et al., 2011 - Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution

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Fig. 2

Expression of Zebrafish lincRNAs (A) Whole-mount in situ hybridizations of selected lincRNAs. Control experiments using sense probes for selected lincRNAs were also performed (Figure S2). (B) Expression levels of lincRNA and protein-coding genes evaluated using RNA-Seq results from ten stages/tissues. Plots indicate the median, quartiles, and 10^th and 90^th percentiles. RPKM is reads per kilobase per million reads. (C) Correlations between levels of neighboring transcripts. For each gene, the Spearman correlation between its expression profile (across ten stages/tissues) and that of the closest protein-coding gene was determined, and the average is plotted for the lincRNA and coding genes. Error bars are 95% confidence intervals based on 1,000 random shuffles of lincRNA positions. See also Figure S2 and Table S4.

Expression Data

Genes:	linc-arid4a linc-cldn7a linc-csnk1a1 linc-elovl1a linc-epb41l4a linc-gtf2f2b linc-mettl3 linc-mipep linc-setd1ba linc-srd5a2a linc-tbx2b linc-trpc7b malat1
Fish:	WT
Anatomical Terms:	brain central nervous system cranial ganglion eye head neuron hindbrain neuron inner ear mandibular arch skeleton mucus secreting cell neuron notochord olfactory epithelium olfactory placode optic cup pronephros spinal cord
Stage Range:	Prim-5 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Cell, 147(7), Ulitsky, I., Shkumatava, A., Jan, C.H., Sive, H., and Bartel, D.P., Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution, 1537-1550, Copyright (2011) with permission from Elsevier. Full text @ Cell