FIGURE

Fig. S3

ID

ZDB-FIG-110920-61

Publication

Bohnsack et al., 2011 - Phenothiourea Sensitizes Zebrafish Cranial Neural Crest and Extraocular Muscle Development to Changes in Retinoic Acid and IGF Signaling

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Fig. S3

PTU alters IGF regulation of neural crest development. 72 hpf Tg(sox10::EGFP) embryos (ventral view) that were injected with morpholinos against igf1ra (A, B), igf1rb (C, D), igf1ra/igf1rb (E, F) or with a control (globin; G, H) and were raised in control media (roy background, A C, E, G) or media supplemented with 0.003% PTU at 12 hpf (B, D, F, H). Morpholino knockdown of igf1ra caused mild developmental delay only in the presence of 0.003% PTU (B compared to A, G, H). Knockdown of igf1rb or both igf1ra and igf1rb inhibited jaw and pharyngeal arch (PA) formation in the presence of 0.003% PTU (D, F), but not in control media (C, E).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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