Fig. 1

Early lethal craniofacial phenotypes. Examples of EL phenotypes are presented. For each, the left hand panels show lateral views of living embryos, middle panels show lateral views of Ab and Alizarin Red (Ab/AR)-stained larvae, and right hand panels show ventral views of Ab/AR-stained larvae. Small arrows point to pharyngeal teeth (pt). For the 69N Lyon mutant, the black arrow indicates a smaller lower jaw of 69N lyon (lyo), the red arrow indicates a rostrocaudally extended ethmoid plate, and the white arrow indicates a shortened Meckel′s cartilage. The black arrowheads point to rudimentary branchial arch cartilages of 69N lyo embryo, and an asterisk indicates the clefted ethmoid plate. The black arrow in the 93N mutant panel indicates aberrant shape of the lower jaw. The black arrows in the 100N mutant panel indicate a reduced lower jaw, Meckel′s cartilage, and ceratohyal cartilage element. Abbreviations: ch, ceratohyal; eth, ethmoid plate; e, eye; M, Meckel′s cartilage; pt, pharyngeal teeth; wt, wild type; ch, 1-5, branchial arches.