FIGURE

Fig. 6

ID

ZDB-FIG-100429-117

Publication

Arslanova et al., 2010 - Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors

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Fig. 6

Automatically acquired images of embryos treated with increasing concentration of GSI or fragments of Gleevec. Images of embryos at 2 dpf (A), 3 dpf (B), and 5 dpf (C) were presented. Untreated embryos and 0.1% DMSO-treated embryos displayed similar phenotypes. Embryos treated with 50 μM DAPT showed a strong phenotype, and much less effect was observed at lower concentrations (5 μM and 0.5 μM). Gleevec was assessed at 100 μM, 10 μM, 1 μM, and embryos showed no phenotypic alteration. Embryos treated with 100 μM of AD95 showed morphologic changes. These changes were not obvious when 50 μM AD95 was used.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Biotechnol.