FIGURE

Fig. 2

ID
ZDB-FIG-100114-11
Publication
Dovey et al., 2009 - Oncogenic NRAS Cooperates with p53 Loss to Generate Melanoma in Zebrafish
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Fig. 2

NRASQ61K cooperates with p53 loss in melanoma formation. (A) Tumor-bearing fish were identified by visual inspection and checked for fluorescence. The box around the tumor is shown in (B) under fluorescent light. (C, D) Tumor-free survival curves are shown. Three hundred and forty-two NRAS1 sibling and 167 NRAS2 sibling fish were inspected weekly for these studies. The location of tumors in NRAS1;p53-/- and NRAS2;p53-/- fish is shown in (E) and (F), respectively. (G, H) Loss of heterozygosity of the wild-type p53 allele is shown. One hundred percentage of NRAS1;p53+/- fish and 57% of NRAS2;p53+/- fish lose the wild-type copy of p53.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Adult

Phenotype Detail
Acknowledgments
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