FIGURE

Fig. 10

ID

ZDB-FIG-090817-18

Publication

McMahon et al., 2009 - Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish

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Fig. 10

Expression of Fgf-target genes is altered in lmx1b morphants. Whole mount in situ hybridization in 24 hpf embryos for erm, pea3, and spry2 (A–C, F–H) and fluorescence in Tg(dusp6:dEGFP) (D, E, I, J). For each Fgf-target gene, note the expansion in periocular and ocular regions and reduction in the MHB. For dusp6:GFP, sections confirmed up-regulation of GFP in the dorsal neural retina, lens, and optic stalk regions (E, J). Sections were counter-stained with propidium iodide to highlight nuclei (red).

Expression Data

Genes:	EGFP etv4 etv5b spry2
Fish:	WT pt6Tg WT + MO2-lmx1bb + MO3-lmx1ba pt6Tg + MO2-lmx1bb + MO3-lmx1ba
Knockdown Reagents:	MO2-lmx1bb MO3-lmx1ba
Anatomical Terms:	eye forebrain midbrain hindbrain boundary optic stalk presumptive neural retina solid lens vesicle (all 6)
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 332(2), McMahon, C., Gestri, G., Wilson, S.W., and Link, B.A., Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish, 287-298, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.