FIGURE

Fig. 5

ID

ZDB-FIG-090506-35

Publication

Waxman et al., 2009 - Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling

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Fig. 5

Increased RA signaling and Hox activity have similar effects on the ALPM. A-L: In situ hybridizations of hand2 (A-F) and gata4 (G-L) in RA-treated, hoxb5b mRNA-injected, and vp-hoxb5b mRNA-injected embryos at the 8-somite stage. D: Injection of 150 pg hoxb5b mRNA can cause a slight anterior shift in hand2 expression in the LPM. B,E,H,K: Low RA (LRA) treatment or injection of 30 pg of vp-hoxb5b mRNA can shift hand2 anteriorly and reduce the length of gata4 expression. The uneven effects on either side of the embryo are likely due to mosaic distribution of the injected mRNA. C,F,I,L: High RA (HRA) treatment or injection of 60 pg of vp-hoxb5b mRNA can eliminate hand2 and gata4 expression. All views are dorsal with anterior up. Asterisks, the anterior head; arrowheads, the anterior and posterior borders of expression in the LPM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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