FIGURE

Fig. 9

ID

ZDB-FIG-080923-10

Publication

Tallafuss et al., 2008 - The Met receptor tyrosine kinase prevents zebrafish primary motoneurons from expressing an incorrect neurotransmitter

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Fig. 9

Met signaling may influence CaP axonal and neurotransmitter phenotypes through the MEK1/2 pathway. All panels show mn2Et transgenic embryos. (a-d″) Embryos at 26 hpf showing GFP (green) and GABA (red); asterisks indicate CaPs or CaP/VaP pairs. (a′,b′,c′,d′) Only the green channel is shown; (a″,b″,c″,d″) only the red channel of the micrographs shown in (a,b,c,d) is shown. CaPs express GABA in U0126-treated embryos (c-c″) and met MO-injected embryos (b-b″) but not in controls (a-a″) or in SB203580-treated embryos (d-d″). (e-h) Some CaPs have both peripheral (arrows) and central (asterisks) axons in U0126-treated embryos (g) and met MO-injected embryos (f); CaPs have only have peripheral axons in controls (e) and in SB203580-treated embryos (h). Scale bars, 10 μm.

Expression Data

Gene:	GFP
Antibody:	Ab1-GABA
Fish:	parga^mn2Et parga^mn2Et + MO1-met + MO2-met
Conditions:	chemical treatment: SB 203580 chemical treatment: (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile
Knockdown Reagents:	MO1-met MO2-met
Anatomical Term:	CaP motoneuron
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	parga^mn2Et + MO1-met + MO2-met
Knockdown Reagents:	MO1-met MO2-met
Observed In:	CaP motoneuron axon
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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