FIGURE

Fig. 11

ID

ZDB-FIG-080620-25

Publication

Li et al., 2000 - Double-stranded RNA injection produces null phenotypes in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 11

Absence of Pax6.1 expression results in severe abnormalities of head development. (A) The 48-h embryos injected with double-stranded control RNA had normal phenotypes. Microinjection of double-stranded Zf-Pax6.1 RNA into single-cell zebrafish embryos resulted in 25% of the embryos having reduced eyes often accompanied by diminished and disorganized forebrains. (B) In situ hybridizations demonstrated that 24-h embryos lack Zf-Pax6.1 expression following double-stranded Zf-Pax6.1 RNA injection into single-cell embryos, although double-stranded control RNA injection had no apparent effect on Zf-pax6.1 expression. Scale bars = 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 217(2), Li, Y.X., Farrell, M.J., Liu, R., Mohanty, N., and Kirby, M.L., Double-stranded RNA injection produces null phenotypes in zebrafish, 394-405, Copyright (2000) with permission from Elsevier. Full text @ Dev. Biol.