FIGURE

Fig. 6

ID

ZDB-FIG-080516-14

Publication

Pendeville et al., 2008 - Zebrafish Sox7 and Sox18 function together to control arterial-venous identity

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Fig. 6

Influence of Shh, VEGF and Notch signaling on Sox7 and Sox18 expression. All embryos are shown at 24 hpf, and pictures were taken from lateral views at the trunk level. (A) Sox7 expression is lost in Smu mutant embryos and in embryos chemically impaired with cyclopamine whereas Sox18 expression is maintained. (B) Embryos treated with a VEGF receptor tyrosine kinase inhibitor show no expression of Sox7. Sox18 still appears expressed in these embryos. (C) Sox7 and Sox18 expression are maintained in Mindbomb mutants that are impaired in the Notch signalling.

Expression Data

Genes:	efnb2a sox7 sox18
Fish:	WT mib1^ta52b/ta52b smo^b641/b641
Conditions:	chemical treatment: Cyclopamine chemical treatment: vascular endothelial growth factor receptor antagonist
Anatomical Terms:	dorsal aorta intersegmental vessel posterior cardinal vein
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT mib1^ta52b/ta52b smo^b641/b641
Conditions:	chemical treatment: Cyclopamine chemical treatment: vascular endothelial growth factor receptor antagonist
Observed In:	vasculogenesis
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 317(2), Pendeville, H., Winandy, M., Manfroid, I., Nivelles, O., Motte, P., Pasque, V., Peers, B., Struman, I., Martial, J.A., and Voz, M.L., Zebrafish Sox7 and Sox18 function together to control arterial-venous identity, 405-416, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.