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Fig. 5

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ZDB-FIG-080506-43

Publication

Faucourt et al., 2001 - The pitx2 homeobox protein is required early for endoderm formation and nodal signaling

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Fig. 5

The response of Xenopus animal caps to microinjection of pitx2 mRNA partially mimics the response to Xnr-1. Embryos at the eight-cell stage were microinjected at the animal pole in each blastomere with 25, 75, or 225 pg of pitx2c, pitx2b, or Xnr-1 mRNA. Animal caps were removed at stage 9 and analyzed at stage 11 by RT-PCR for expression of the marker genes indicated. 2RT, control without reverse transcription. pitx2 dose-dependently induces goosecoid, sox17β, cerberus, and antivin but not Xbra or chordin. These results are representative of four independent experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 229(2), Faucourt, M., Houliston, E., Besnardeau, L., Kimelman, D., and Lepage, T., The pitx2 homeobox protein is required early for endoderm formation and nodal signaling, 287-306, Copyright (2001) with permission from Elsevier. Full text @ Dev. Biol.