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Fig. 3

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ZDB-FIG-071001-81

Publication

Mizoguchi et al., 2006 - Fgf signaling negatively regulates Nodal-dependent endoderm induction in zebrafish

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Fig. 3

Fgf signaling does not affect bon and fau/gata5 expression. (A–L) All images are lateral views with anterior to the top. These are magnified views of zebrafish embryos around the marginal region at the 40% epiboly stage (5 hpf). (A–B, E–F, I–J) DMSO, SU5402: oep mRNA was injected into WT embryos, and these injected embryos were subsequently treated with either DMSO or SU5402 from the one cell stage to the 40% epiboly stage. Neither the bon nor the fau/gata5 expression levels are affected, whereas mezzo expression is barely detectable, in SU5402-treated embryos. (C–D, G–H, K–L) Overexpression of CA-mek mRNA in WT embryos does not alter the bon or fau/gata5 expression levels, whereas mezzo expression around the marginal region is increased in the CA-mek mRNA-injected embryos.

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Reprinted from Developmental Biology, 300(2), Mizoguchi, T., Izawa, T., Kuroiwa, A., and Kikuchi, Y., Fgf signaling negatively regulates Nodal-dependent endoderm induction in zebrafish, 612-622, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.