FIGURE

Fig. 1

ID

ZDB-FIG-070914-63

Publication

Steffen et al., 2007 - The zebrafish runzel muscular dystrophy is linked to the titin gene

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Fig. 1

Skeletal muscle is severely disorganized in ruz mutants. (A) Wild-type fish skeletal muscle is highly birefringent at 5–6 dpf. (B) 5–6 dpf ruz homozygous mutants show decreased skeletal muscle birefringence and, on a TL background, body curvature. (C, D) Longitudinal sections of zebrafish skeletal muscle at 5 dpf were stained with hematoxylin. (C) Wild-type muscle shows myofiber alignment between myosepta and peripherally localized nuclei. (D) ruz muscle myofibers appear unaligned with abnormally shaped nuclei. Arrows indicate myosepta.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ruz^tk258/tk258 (TL)
Observed In:	heart larval locomotory behavior neuromuscular process controlling posture skeletal muscle cell myofibril skeletal muscle cell nucleus skeletal myofibril assembly somite skeletal muscle cell swim bladder inflation trunk (all 9)
Stage Range:	Day 5 to Day 6

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 309(2), Steffen, L.S., Guyon, J.R., Vogel, E.D., Howell, M.H., Zhou, Y., Weber, G.J., Zon, L.I., and Kunkel, L.M., The zebrafish runzel muscular dystrophy is linked to the titin gene, 180-192, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.