FIGURE

Fig. 4

ID
ZDB-FIG-070608-8
Publication
Hall et al., 2007 - The zebrafish candyfloss mutant implicates extracellular matrix adhesion failure in laminin {alpha}2-deficient congenital muscular dystrophy
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Fig. 4

Immunohistochemistry at 72 hpf shows retraction of epitopes with detaching fibers, demonstrating that failure occurs within the extracellular matrix rather than at the sarcolemma. (A) caf, anti-dystrophin. (B) Wild-type anti-dystrophin. (C) caf, anti-β-dystroglycan. (D) Wild-type anti-β-dystroglycan. (E) caf, anti-laminin 1. (F) Wild-type anti-laminin 1. (i) Flourescence, (ii) DIC, and (iii) merge. Arrowheads indicate retraction of epitopes with individual fibers. Images show lateral views, anterior to the left.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Protruding-mouth

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA