FIGURE

Fig. 5

ID

ZDB-FIG-050725-6

Publication

Cha et al., 2005 - Cyclooxygenase-1 signaling is required for vascular tube formation during development

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Fig. 5

Inhibition of COX-1 does not cause defect in somite formation or VEGF production. Vinculin staining, marker for intersomitic boundary, reveals normal somite formation in the trunk both in control group (A) and treated group (B). In the tail region, vinculin staining is overlayed on DIC image of the same area. It also reveals that somite formation of the tail is unchanged in control group (C) vs. treated group (D). Somites in the treated embryos produce normal amounts of VEGF (F), compared to the untreated group (E).

Expression Data

Gene:	vegfaa
Fish:	WT
Condition:	chemical treatment: indometacin
Anatomical Term:	somite
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 282(1), Cha, Y.I., Kim, S.H., Solnica-Krezel, L., and Dubois, R.N., Cyclooxygenase-1 signaling is required for vascular tube formation during development, 274-283, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.