FIGURE

Fig. 7

ID

ZDB-FIG-050725-10

Publication

Cha et al., 2005 - Cyclooxygenase-1 signaling is required for vascular tube formation during development

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Fig. 7

cox1-MO causes posterior mesoderm defect similar to indomethacin-induced phenotype. Compared to uninjected wild-type (A), injection of 8 ng cox1-MO (B) specifically disrupted posterior mesoderm organs at 1 day, including enlarged nephric duct and distended posterior vasculature (B, arrow). Staining with pax2.1 shows increased pronephric duct size in the posterior region (D). As the embryos develop, the increased staining correlates to increase in posterior nephric duct size at day 2 (H, arrow) and day 3 (I, arrow), compared to wild-type (E, F).

Expression Data

Gene:	pax2a
Fish:	WT WT + MO1-ptgs1
Knockdown Reagent:	MO1-ptgs1
Anatomical Term:	pronephric duct
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 282(1), Cha, Y.I., Kim, S.H., Solnica-Krezel, L., and Dubois, R.N., Cyclooxygenase-1 signaling is required for vascular tube formation during development, 274-283, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.