FIGURE

Fig. 2

ID

ZDB-FIG-050513-2

Publication

Filippi et al., 2005 - The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord

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Fig. 2

olig3 controls specification of the neural crest. (a–d) The levels and the expression domains of sox10 and foxd3 are decreased in four-somite embryos injected with olig3 mRNA (b and d) (phenotype in >90% of injected embryos, n = 30). (e and f) The expression of foxd3 is increased in 15-somite embryos treated with olig3MO (f) (morphant phenotype > 90%, n = 20). Similarly, the expression of crestin is increased in 30-hpf embryos treated with olig3MO (h and f) (morphant phenotype > 90%, n = 40). Similar results are obtained in 24-hpf embryos hybridized with sox10 (k and l) (morphant phenotype > 90%, n = 30). Embryos are in dorsal (a–h, k, and l) or lateral (i and j) view, anterior to the top (a–d) or to the left (e–l).

Expression Data

Genes:	crestin foxd3 sox10
Fish:	WT WT + MO2-olig4
Knockdown Reagent:	MO2-olig4
Anatomical Terms:	mesenchyme derived from trunk neural crest neural crest peripheral nervous system
Stage Range:	14-19 somites to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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