Genomic Feature
baz1
- ID
- ZDB-ALT-070131-1
- Name
- baz1
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Bath Zebrafish Development Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 3: 1495001 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Val>Met at position 117 (1)
- Flanking Sequence
-
CTGGATGATCTTAAATAATAAACAAAAGCACAGTTGTTTTACAAGAAAAAACATTTGTAAAGTATAAATAAATACATTTATATTTAAGATAAAATTTAAGTGAGGAAATTAGACCTACCGAAGTCACCTGTGGCCGCAGAACGAGTGGACCGATGTCGGCGGAGGAGCACAGCATGTCGGAGGTGGAAATGAGTCCCGGGGTGTCGGACGATGGGCACTCCATGTCCCCTGGTCACTCGTCGGGCGCTCCAGGTGGCGCGGACTCCCCTCTGCCCGGTCAGCAGTCTCAGATGTCCGGGATCGGGGATGATGGAGCCGGTGTCTCCGGCGGGGTCTCAGTGAAGTCCGACGAGGAAGATGACCGGTTCCCCATCGGCATCCGCGAGGCGGTCAGTCAGGTGCTGAACGGGTACGACTGGACGCTCGTGCCCATGCCCGTGCGCGTGAACTCGGGCAGCAAGAGCAAACCGCACGTCAAGCGGCCGATGAACGCGTTCATG
G/A TGTGGGCGCAGGCCGCGCGCAGGAAACTGGCGGATCAATATCCGCACCTGCACAACGCCGAGCTCAGCAAAACACTGGGGAAGCTGTGGAGGTGAGCGCGCACGAATGATGCTTTACCTGTAAACGCACTGCTACAACAGGACTGTTGCGCCACCATGTTGCAGTACAATGTGTAAAATAAAGAGCTAAATATCATACACACATACATATAGTACTAAACAGGGGTTAGTTCACCCCAAAAATGAAACTGTACGCACTATTTACTCAGTCAAGTGGTTTCAAACTTCAAAGTTTTTTCTTTAGTTAAACATTAAAGAAGATATATATATATATATATATATATATATATATATATATATATATATATATATATATATACATTTCCATTGTAGGAAAACAAATGGAAGTCAATGGTTTCAAACATTTTTCAAACTATCTTATTTTGTGCTCAACAGAAGAAACTAAAGGTTTATATAAGTATAAATAATGATTAAAGAGTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| sox10baz1/baz1 | Homozygous | ♀+/- ♂+/- | 3 figures  from 3 publications | 3 figures from 3 publications | |
| sox10baz1/+ | Heterozygous | ♀+/- ♂+/- | Fig. S5 from Dooley et al., 2019 | ||
| sox10baz1/+; sox10t3/+ | Complex | ||||
| sox10baz1/baz1; sox5nub13/nub13 | Complex | Fig. 5 from Nagao et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Dooley, C.M., Wali, N., Sealy, I.M., White, R.J., Stemple, D.L., Collins, J.E., Busch-Nentwich, E.M. (2019) The gene regulatory basis of genetic compensation during neural crest induction. PLoS Genetics. 15:e1008213
- Nagao, Y., Takada, H., Miyadai, M., Adachi, T., Seki, R., Kamei, Y., Hara, I., Taniguchi, Y., Naruse, K., Hibi, M., Kelsh, R.N., Hashimoto, H. (2018) Distinct interactions of Sox5 and Sox10 in fate specification of pigment cells in medaka and zebrafish. PLoS Genetics. 14:e1007260
- Delfino-Machín, M., Madelaine, R., Busolin, G., Nikaido, M., Colanesi, S., Camargo-Sosa, K., Law, E.W., Toppo, S., Blader, P., Tiso, N., Kelsh, R.N. (2017) Sox10 contributes to the balance of fate choice in dorsal root ganglion progenitors. PLoS One. 12:e0172947
- Fazenda, C., Conceição, N., Cancela, M.L. (2015) Transcription factors from Sox family regulate expression of zebrafish Gla-rich protein 2 gene. Gene. 572(1):57-62
- Dyer, C., Linker, C., Graham, A., Knight, R. (2014) Specification of sensory neurons occurs through diverse developmental programs functioning in the brain and spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(11):1429-39
- Carney, T.J., Dutton, K.A., Greenhill, E., Delfino-Machin, M., Dufourcq, P., Blader, P., and Kelsh, R.N. (2006) A direct role for Sox10 in specification of neural crest-derived sensory neurons. Development (Cambridge, England). 133(23):4619-4630
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