ZFIN ID: ZDB-LAB-111128-1
Melmed Lab
PI/Director: Melmed, Shlomo
Co-PI / Senior
Researcher:		 Liu, Ning-Ai
Contact Person: Ren, Song-Guang
Email: Song-Guang.Ren@cshs.org
URL: http://www.cedars-sinai.edu/Research-and-Education/Research-Labs/Molecular-Endocrinology-Laboratory.aspx
Address: Cedars-Sinai Medical Center 8700 Beverly Blvd., Davis 3025 Los Angeles, CA 90048
Country: United States
Phone: (310) 423-4691
Fax: (310) 423-0119
Line Designation: csz


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 3 genomic features


STATEMENT OF RESEARCH INTERESTS
Understanding molecular and cellular mechanisms of hormone-secreting tumors using cellular, murine and zebrafish experimental models; and developing therapies for patients with non-functioning pituitary tumors, Cushing’s disease, prolactinomas and acromegaly that are resistant to current treatments. Our study will enable further insights into the role of cell cycle control and growth constraint of experimental and human pituitary tumors, underlying their failure to progress to malignancy.


LAB MEMBERS
Parsa, Alan Post-Doc Jiang, Hong Research Staff Ren, Song-Guang Administrative Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Liu, N.A., Araki, T., Cuevas-Ramos, D., Hong, J., Ben-Shlomo, A., Tone, Y., Tone, M., Melmed, S. (2015) Cyclin E - mediated human proopiomelanocortin regulation as a therapeutic target for Cushing disease. The Journal of clinical endocrinology and metabolism. 100(7):2557-64
Xu, N., Chua, A.K., Jiang, H., Liu, N.A., Goodarzi, M.O. (2014) Early Embryonic Androgen Exposure Induces Transgenerational Epigenetic and Metabolic Changes. Molecular endocrinology (Baltimore, Md.). 28(8):1329-36
Wang, X., Dong, Q., Chen, Y., Jiang, H., Xiao, Q., Wang, Y., Li, W., Bai, C., Huang, C., and Yang, D. (2013) Bisphenol A affects axonal growth, musculature and motor behavior in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 142-143C:104-113
Huang, H., Lindgren, A., Wu, X., Liu, N.A., and Lin, S. (2012) High-throughput screening for bioactive molecules using primary cell culture of transgenic zebrafish embryos. Cell Reports. 2(3):695-704
Yang, Z., Jiang, H., Chachainasakul, T., Gong, S., Yang, X.W., Heintz, N., and Lin, S. (2006) Modified bacterial artificial chromosomes for zebrafish transgenesis. Methods (San Diego, Calif.). 39(3):183-188
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