FIGURE SUMMARY
Title

Three New α-Pyrone Derivatives with Antiepileptic Activity from the Marine Actinomycete Nocardiopsis sp. NBUDK19

Authors
Li, J., Zhou, Z., Feng, F., Yuan, W., Zhang, Y., Wang, J., Zhang, B., Jin, H., He, S., Ding, L.
Source
Full text @ Mar. Biotechnol.
Fig. 1

Structures of isolated compounds 1 − 3

Fig. 2

The key COSY and HMBC correlations of 1 − 3

Fig. 3

Specific rotation comparison of compounds 1 and 3 at CAM-B3LYP/aug-cc-PVTZ level in MeOH using PCM model

Fig. 4

Compounds 1 − 3 (5 μg/mL) ameliorate behavioral deficits induced by PTZ. A Representative movement trajectories in dark conditions (n = 20). B, C, D, E, F, and G Total distance, movement time, average speed, highly mobile frequency, mobile cumulative duration time, and center-point relative total under 15-min stimulation. (Mean ± S.D.; *** p < 0.001; distinct lowercase letters indicate significant differences among the rescue groups)

Fig. 5

A, B, and C Changes in gene expression for the control and compounds 1 − 3 (5 μg/mL) treated groups before and after PTZ treatment, as shown for c-fos, gria1b, and gat1 expression level (Mean ± S.D; ** p < 0.01, * p < 0.05; The same lowercase letters indicate no significant differences among the rescue groups; ns, no significance)

Fig. 6

Molecular docking of compounds 1 − 3. D, E, and F 3D and 2D diagrams that illustrate the modeled binding site of the 4-aminobutyrate aminotransferase protein with the ligand compounds 1 − 3

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mar. Biotechnol.
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