FIGURE SUMMARY
Title

Physiology-informed toxicokinetic model for the zebrafish embryo test developed for bisphenols

Authors
Chelcea, I., Vogs, C., Hamers, T., Koekkoek, J., Legradi, J., Sapounidou, M., Örn, S., Andersson, P.L.
Source
Full text @ Chemosphere
Fig. 1

Structure of the TK model represented for three developmental stages: i) between 0% until 100% epiboly (around 10 hpf) ii) between around 10 hpf until hatching (60 hpf), and iii) > 60 hpf hatching. Arrows represent mass flow of compound between compartments.

Fig. 2

Model prediction of internal zebrafish embryo (ZFE) amounts compared with measured amounts (dots) for BPZ (A), BPA (B) and BPAF (C) from current study at 4–120 hpf exposure.

Fig. 3

Observed and predicted amount (nmol) of compound per ZFE (embryo body, yolk and chorion) for BPA (A), BPAF, BPF, TBBPA (B), BPS and BP-2 (C). Solid line represents 1:1 correlation and dotted lines represent the 2-fold (black) and 5-fold- (gray) errors. R2 was calculated for each graph. Note that all data presented in this Figure was not used in model calibration.

Fig. Abs

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Chemosphere
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