- Title
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Neuroprotective Effect of Yucca schidigera Roezl ex Ortgies Bark Phenolic Fractions, Yuccaol B and Gloriosaol A on Scopolamine-Induced Memory Deficits in Zebrafish
- Authors
- Pecio, Ł., Kozachok, S., Brinza, I., Boiangiu, R.S., Hritcu, L., Mircea, C., Burlec, A.F., Cioanca, O., Hancianu, M., Wronikowska-Denysiuk, O., Skalicka-Woźniak, K., Oleszek, W.
- Source
- Full text @ Molecules
The structure of spiro-flavostilbenoids: (A) Yuccaol B (YuB); (B) Gloriosaol A (GloA). |
2D-HSQC- (A) and 2D-HMBC-NMR (B) spectra (in acetone-d6:D2O, 7:3) of the polymeric fraction (YS poly) isolated from Y. schidigera cortex. Top black trace: 1H NMR spectrum of YS poly. |
The effects of YS preparations (1, 3 and 5 μg/L) on memory and locomotor activity in scopolamine (Sco)-treated zebrafish in the Y-maze test. Memory: time spent in each arm (start, other and novel arm); Locomotion: total distance traveled and Turn angle of zebrafish in the tank in the control—untreated group; group treated with scopolamine (Sco 100 µM); groups treated with Sco (100 µM) and (a) YS pur—purified fraction; (b) YS poly—polymeric fraction; (c) YuB—yuccaol B; and (d) GloA—gloriosaol A. Values are means ± S.E.M. (n = 10). For Tukey’s post hoc analyses * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. PHENOTYPE:
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The influence of Y. schidigera preparations in scopolamine (Sco)-treated zebrafish on locomotor activity and anxiety level observed in the Novel Tank Diving Test (NTT). Anxiety response: time spent in the top (s); Locomotion: distance top/bottom ratio; and Velocity (m/s) in the control group; group treated with Sco 100 µM; groups treated with Sco (100 µM) and yucca preparations at 1, 3, 5 µg/L: (a) YS pur—purified fraction; (b) YS poly—polymeric fraction; (c) YuB—Yuccaol B; (d) GloA—Gloriosaol A. Values are means ± S.E.M. (n = 10). For Tukey’s post hoc analyses * p < 0.05, ** p < 0.01 and *** p < 0.001. PHENOTYPE:
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