PUBLICATION
Neuroprotective Effect of Yucca schidigera Roezl ex Ortgies Bark Phenolic Fractions, Yuccaol B and Gloriosaol A on Scopolamine-Induced Memory Deficits in Zebrafish
- Authors
- Pecio, Ł., Kozachok, S., Brinza, I., Boiangiu, R.S., Hritcu, L., Mircea, C., Burlec, A.F., Cioanca, O., Hancianu, M., Wronikowska-Denysiuk, O., Skalicka-Woźniak, K., Oleszek, W.
- ID
- ZDB-PUB-220625-20
- Date
- 2022
- Source
- Molecules 27(12): (Journal)
- Registered Authors
- Keywords
- Asparagaceae, Yucca schidigera, anxiety, cholinergic function, memory, oxidative stress, polyphenols, spiro-flavostilbenoids, stilbenoids, zebrafish
- MeSH Terms
-
- Acetylcholinesterase
- Animals
- Antioxidants/analysis
- Antioxidants/pharmacology
- Butyrylcholinesterase
- Memory Disorders/chemically induced
- Memory Disorders/drug therapy
- Neuroprotective Agents*/analysis
- Neuroprotective Agents*/pharmacology
- Phenols/chemistry
- Plant Bark/chemistry
- Plant Extracts/chemistry
- Scopolamine/adverse effects
- Scopolamine/analysis
- Yucca*/chemistry
- Zebrafish
- PubMed
- 35744815 Full text @ Molecules
Citation
Pecio, Ł., Kozachok, S., Brinza, I., Boiangiu, R.S., Hritcu, L., Mircea, C., Burlec, A.F., Cioanca, O., Hancianu, M., Wronikowska-Denysiuk, O., Skalicka-Woźniak, K., Oleszek, W. (2022) Neuroprotective Effect of Yucca schidigera Roezl ex Ortgies Bark Phenolic Fractions, Yuccaol B and Gloriosaol A on Scopolamine-Induced Memory Deficits in Zebrafish. Molecules. 27(12).
Abstract
Y. schidigera contains a number of unusual polyphenols, derivatives of resveratrol and naringenin, called spiro-flavostilbenoids, which have potent in vitro anti-inflammatory, antioxidant, and moderate cholinesterase inhibitory activities. To date, these compounds have not been tested in vivo for the treatment of neurodegenerative diseases. The aim of the present study was to evaluate the effects of both single spiro-flavostilbenoids (yuccaol B and gloriosaol A) and phenolic fractions derived from Y. schidigera bark on scopolamine-induced anxiety and memory process deterioration using a Danio rerio model. Detailed phytochemical analysis of the studied fractions was carried out using different chromatographic techniques and Nuclear Magnetic Resonance (NMR). The novel tank diving test was used as a method to measure zebrafish anxiety, whereas spatial working memory function was assessed in Y-maze. In addition, acetylcholinesterase/butyrylcholinesterase (AChE/BChE) and 15-lipooxygenase (15-LOX) inhibition tests were performed in vitro. All pure compounds and fractions under study exerted anxiolytic and procognitive action. Moreover, strong anti-oxidant capacity was observed, whereas weak inhibition towards cholinesterases was found. Thus, we may conclude that the observed behavioral effects are complex and result rather from inhibition of oxidative stress processes and influence on cholinergic muscarinic receptors (both 15-LOX and scopolamine assays) than effects on cholinesterases. Y. schidigera is a source of substances with desirable properties in the prevention and treatment of neurodegenerative diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping