FIGURE SUMMARY
- Title
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New Sorbicillinoids with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus Hypocrea jecorina H8
- Authors
- Liu, S.Z., Xu, G.X., He, F.M., Zhang, W.B., Wu, Z., Li, M.Y., Tang, X.X., Qiu, Y.K.
- Source
- Full text @ Mar. Drugs
Figure 1. Structures of compounds 1–11 isolated from an extract of Hypocrea jecorina H8; the relative configuration of 5 is reported in this article.
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Figure 2. Key 1H–1H COSY, HMBC, and NOESY correlations of compounds 1–5. (a) Key COSY, HMBC, and NOESY correlations of compounds 1; (b) Key COSY, HMBC, and NOESY correlations of compounds 2; (c) Key COSY, HMBC, and NOESY correlations of compounds 3; (d) Key COSY, HMBC correlations of compounds 4; (e) Key COSY, HMBC, and NOESY correlations of compounds 5.
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Figure 3. Calculated and experimental ECD spectra of compounds 1, 2, and 3. (a) ECD spectra for compound 1; (b) ECD spectra for compound 2; (c): ECD spectra for compound 3.
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Figure 4. Embryotoxicity and developmental toxicity assay; 15 zebrafish embryos per condition were exposed to compounds at the concentrations of 10, 5, 2.5, 1.25, and 0.625 μM, and 0.1% DMSO was used as blank control. (a) The mortality rate of 24 embryo treated with compounds; (b) The mortality rate of 72 embryo treated with compounds; (c) The impact on the malformation of zebrafish treated with compounds) The statistics of 24 and 72 h mortality rate; © Morphology of 24 h embryo or 72 h zebrafish larvae treated with compounds or control.
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Acknowledgments
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Full text @ Mar. Drugs