PUBLICATION
New Sorbicillinoids with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus Hypocrea jecorina H8
- Authors
- Liu, S.Z., Xu, G.X., He, F.M., Zhang, W.B., Wu, Z., Li, M.Y., Tang, X.X., Qiu, Y.K.
- ID
- ZDB-PUB-220325-6
- Date
- 2022
- Source
- Marine drugs 20(3): (Journal)
- Registered Authors
- Li, Mingyu
- Keywords
- Hypocrea jecorina H8, tea pathogenic fungus inhibitory effect, toxicity assessment, trichodermolide C, D
- MeSH Terms
-
- Animals
- Ascomycota/drug effects*
- Ascomycota/growth & development
- Biological Control Agents*/chemistry
- Biological Control Agents*/isolation & purification
- Biological Control Agents*/pharmacology
- Biological Control Agents*/toxicity
- Camellia sinensis/microbiology
- Embryo, Nonmammalian
- Hypocreales/chemistry*
- Molecular Structure
- Polyketides*/chemistry
- Polyketides*/isolation & purification
- Polyketides*/pharmacology
- Polyketides*/toxicity
- Zebrafish
- PubMed
- 35323512 Full text @ Mar. Drugs
Citation
Liu, S.Z., Xu, G.X., He, F.M., Zhang, W.B., Wu, Z., Li, M.Y., Tang, X.X., Qiu, Y.K. (2022) New Sorbicillinoids with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus Hypocrea jecorina H8. Marine drugs. 20(3):.
Abstract
Four new dimeric sorbicillinoids (1-3 and 5) and a new monomeric sorbicillinoid (4) as well as six known analogs (6-11) were purified from the fungal strain Hypocrea jecorina H8, which was obtained from mangrove sediment, and showed potent inhibitory activity against the tea pathogenic fungus Pestalotiopsis theae (P. theae). The planar structures of 1-5 were assigned by analyses of their UV, IR, HR-ESI-MS, and NMR spectroscopic data. All the compounds were evaluated for growth inhibition of tea pathogenic fungus P. theae. Compounds 5, 6, 8, 9, and 10 exhibited more potent inhibitory activities compared with the positive control hexaconazole with an ED50 of 24.25 ± 1.57 µg/mL. The ED50 values of compounds 5, 6, 8, 9, and 10 were 9.13 ± 1.25, 2.04 ± 1.24, 18.22 ± 1.29, 1.83 ± 1.37, and 4.68 ± 1.44 µg/mL, respectively. Additionally, the effects of these compounds on zebrafish embryo development were also evaluated. Except for compounds 5 and 8, which imparted toxic effects on zebrafish even at 0.625 μM, the other isolated compounds did not exhibit significant toxicity to zebrafish eggs, embryos, or larvae. Taken together, sorbicillinoid derivatives (6, 9, and 10) from H. jecorina H8 displayed low toxicity and high anti-tea pathogenic fungus potential.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping