FIGURE SUMMARY
Title

Downregulation of Nodal inhibits metastatic progression in retinoblastoma

Authors
Asnaghi, L., White, D.T., Yoon, L., Price, A., Lee, G.Y., Sahoo, A., Mumm, J.S., Eberhart, C.G.
Source
Full text @ Acta Neuropathol Commun
Fig. 4

Reduction of Nodal inhibits invasion of Y79 cells in zebrafish.  a Representative images of the localization of Y79-GFP cells (highlighted in green) expressing Nodal shRNA (sequence A) or scrambled shRNA at 1 and 4 dpi after intravitreal injection in zebrafish.  b We observed 34% reduction in the fold-change of the minimum bounding sphere (MBS, highlighted in red, 50 μm grid for scale) diameter (μm) between day 1 and day 4 post-injection images when zebrafish larvae ( n = 24) were injected intravitreally with Y79-GFP cells expressing Nodal shRNA, compared to scrambled shRNA ( n = 23). Effect size: -0.44; 95% CI: − 0.67, − 0.22;  p = 2.96 × 10− 4; 50 μm grid for scale
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Acta Neuropathol Commun
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