FIGURE SUMMARY
Title

Potent and selective in vitro and in vivo antiproliferative effects of metal-organic trefoil knots

Authors
Benyettou, F., Prakasam, T., Ramdas Nair, A., Witzel, I.I., Alhashimi, M., Skorjanc, T., Olsen, J.C., Sadler, K.C., Trabolsi, A.
Source
Full text @ Chem Sci
Fig. 3

M-TKs induce apoptosis in zebrafish embryos. (a) Treatment timeline for zebrafish embryos. (b) Sequence of death in 24 hpf live zebrafish embryos post treatment with M-TKs. (c) Dose–response curve for M-TKs, cisplatin, and metal-free TK. Dotted line indicates LD50. (d) Kaplan–Meier plot displaying the survival trend after treatment with M-TKs, cisplatin, and metal-free TK at a fixed concentration of 4 μM. (e) Representative images of control, TK- and Cu-TK-treated embryos. Top row – acridine orange assay. Middle row – TUNEL assay. Yellow boxes indicate area analyzed for TUNEL-positive cells. Bottom row – higher magnification inserts corresponding to the yellow boxes in the middle row. (f) Quantification of TUNEL-positive cells in control, TK-, and Cu-TK-treated zebrafish embryos. All values are expressed as mean ± STD. (n= 3). *P < 0.05, **P < 0.01 and ***P < 0.001 compared to the control.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Chem Sci
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