PUBLICATION
Potent and selective in vitro and in vivo antiproliferative effects of metal-organic trefoil knots
- Authors
- Benyettou, F., Prakasam, T., Ramdas Nair, A., Witzel, I.I., Alhashimi, M., Skorjanc, T., Olsen, J.C., Sadler, K.C., Trabolsi, A.
- ID
- ZDB-PUB-190801-13
- Date
- 2019
- Source
- Chemical science 10: 5884-5892 (Journal)
- Registered Authors
- Sadler Edepli, Kirsten C.
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 31360392 Full text @ Chem Sci
Citation
Benyettou, F., Prakasam, T., Ramdas Nair, A., Witzel, I.I., Alhashimi, M., Skorjanc, T., Olsen, J.C., Sadler, K.C., Trabolsi, A. (2019) Potent and selective in vitro and in vivo antiproliferative effects of metal-organic trefoil knots. Chemical science. 10:5884-5892.
Abstract
A set of metal-organic trefoil knots (M-TKs) generated by metal-templated self-assembly of a simple pair of chelating ligands were well tolerated in vitro by non-cancer cells but were significantly more potent than cisplatin in both human cancer cells--including those resistant to cisplatin--and in zebrafish embryos. In cultured cells, M-TKs generated reactive oxygen species that triggered apoptosis via the mitochondrial pathway without directly disrupting the cell-membrane or damaging nuclear DNA. The cytotoxicity and wide scope for structural variation of M-TKs indicate the potential of synthetic metal-organic knots as a new field of chemical space for pharmaceutical design and development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping