- Title
-
Survey of Human Chromosome 21 Gene Expression Effects on Early Development in Danio rerio.
- Authors
- Edie, S., Zaghloul, N.A., Leitch, C.C., Klinedinst, D.K., Lebron, J., Thole, J.F., McCallion, A.S., Katsanis, N., Reeves, R.H.
- Source
- Full text @ G3 (Bethesda)
Flowchart showing steps of making the Hsa21 Gene Expression Clone-set and the screen in zebrafish. |
Examples of phenotypes observed in the screen. Control embryos are on the left panel and injected embryos are on the right panel. Somites: RWDD2B 100pg injected embryos at 24 hpf with dashed lines to highlight somitic boundaries. Cyclopia: C21ORF84 100pg injected embryos at 5 dpf. Pigment cell migration: CCT8 100pg injected embryos at 4 dpf, arrows indicating melanocytes. Heart: JAM2 100pg injected embryos at 48 hpf. |