ZFIN Lab: Immunology and Genomics Lab

ZFIN ID: ZDB-LAB-240215-1

Immunology and Genomics Lab

PI/Director:	Novoa, Beatriz
Co-PI / Senior Researcher:	Figueras, Antonio
Contact Person:	Novoa, Beatriz
Email:	beatriznovoa@iim.csic.es
URL:	https://www.iim.csic.es/index.php/en/research/all-groups/immunology-genomics
Address:	Immunology and Genomics Group Institute of Marine Research. CSIC. Eduardo Cabello 6. 36208 Vigo, Spain
Country:	Spain
Phone:
Fax:
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

We are interested in the immune response against infections, specially viral pathogens. We work on the molecular basis of this response using omic tools.Also we study the inflammatory response and the relationship with external and internal factors such as microbiome.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

González-Rodríguez, L., Pérez-Davila, S., Lama, R., López-Álvarez, M., Serra, J., Novoa, B., Figueras, A., González, P. (2023) 3D printing of PLA:CaP:GO scaffolds for bone tissue applications. RSC Advances. 13:159471595915947-15959

Pereiro, P., Rey-Campos, M., Figueras, A., Novoa, B. (2023) An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Danio rerio) and increases susceptibility to virus infection. Frontiers in immunology. 13:11000921100092

Pérez-Davila, S., González-Rodríguez, L., Lama, R., López-Álvarez, M., Oliveira, A.L., Serra, J., Novoa, B., Figueras, A., González, P. (2022) 3D-Printed PLA Medical Devices: Physicochemical Changes and Biological Response after Sterilisation Treatments. Polymers. 14(19):

Lama, R., Pereiro, P., Figueras, A., Novoa, B. (2022) Zebrafish as a Vertebrate Model for Studying Nodavirus Infections. Frontiers in immunology. 13:863096

Sendra, M., Pereiro, P., Yeste, M.P., Novoa, B., Figueras, A. (2021) Surgical face masks as a source of emergent pollutants in aquatic systems: Analysis of their degradation product effects in Danio rerio through RNA-Seq. Journal of hazardous materials. 428:128186

Pereiro, P., Lama, R., Figueras, A., Novoa, B. (2021) Characterization of the turbot (Scophthalmus maximus) interleukin-18: Identification of splicing variants, phylogeny, synteny and expression analysis. Developmental and comparative immunology. 124:104199

Bello-Perez, M., Adamek, M., Coll, J., Figueras, A., Novoa, B., Falco, A. (2021) Modulation of the Tissue Expression Pattern of Zebrafish CRP-Like Molecules Suggests a Relevant Antiviral Role in Fish Skin. Biology. 10(2)

Sendra, M., Pereiro, P., Yeste, M.P., Mercado, L., Figueras, A., Novoa, B. (2020) Size matters: Zebrafish (Danio rerio) as a model to study toxicity of nanoplastics from cells to the whole organism. Environmental pollution (Barking, Essex : 1987). 268:115769

Pereiro, P., Figueras, A., Novoa, B. (2020) Zebrafish pten Genes Play Relevant but Distinct Roles in Antiviral Immunity. Vaccines. 8(2):

Pereiro, P., Librán-Pérez, M., Figueras, A., Novoa, B. (2020) Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator. Developmental and comparative immunology. 109:103698

Pereiro, P., Álvarez-Rodríguez, M., Valenzuela-Muñoz, V., Gallardo-Escárate, C., Figueras, A., Novoa, B. (2020) RNA-Seq analysis reveals that spring viraemia of carp virus induces a broad spectrum of PIM kinases in zebrafish kidney that promote viral entry. Fish & shellfish immunology. 99:86-98

Bello-Perez, M., Pereiro, P., Coll, J., Novoa, B., Perez, L., Falco, A. (2020) Zebrafish C-reactive protein isoforms inhibit SVCV replication by blocking autophagy through interactions with cell membrane cholesterol. Scientific Reports. 10:566

Rey-Campos, M., Moreira, R., Romero, A., Medina-Gali, R.M., Novoa, B., Gasset, M., Figueras, A. (2020) Transcriptomic Analysis Reveals the Wound Healing Activity of Mussel Myticin C. Biomolecules. 10(1):

Librán-Pérez, M., Pereiro, P., Figueras, A., Novoa, B. (2019) Antiviral activity of palmitic acid via autophagic flux inhibition in zebrafish (Danio rerio). Fish & shellfish immunology. 95:595-605

Valenzuela-Muñoz, V., Pereiro, P., Álvarez-Rodríguez, M., Gallardo-Escárate, C., Figueras, A., Novoa, B. (2019) Comparative modulation of lncRNAs in wild-type and rag1-heterozygous mutant zebrafish exposed to immune challenge with spring viraemia of carp virus (SVCV). Scientific Reports. 9:14174

Novoa, B., Pereiro, P., López-Muñoz, A., Varela, M., Forn-Cuní, G., Anchelin, M., Dios, S., Romero, A., Martinez-López, A., Medina-Gali, R.M., Collado, M., Coll, J., Estepa, A., Cayuela, M.L., Mulero, V., Figueras, A. (2019) Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress. Aging Cell. 18(5):e13020

Falco, A., Medina-Gali, R.M., Poveda, J.A., Bello-Perez, M., Novoa, B., Encinar, J.A. (2019) Antiviral Activity of a Turbot (Scophthalmus maximus) NK-Lysin Peptide by Inhibition of Low-pH Virus-Induced Membrane Fusion. Marine drugs. 17(2)

Bello-Perez, M., Falco, A., Novoa, B., Perez, L., Coll, J. (2019) Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms. PLoS One. 14:e0201509

Medina-Gali, R.M., Belló-Pérez, M., Ciordia, S., Mena, M.C., Coll, J., Novoa, B., Ortega-Villaizán, M.D.M., Perez, L. (2018) Plasma proteomic analysis of zebrafish following spring viremia of carp virus infection. Fish & shellfish immunology. 86:892-899

Johansen, M.D., Hortle, E., Kasparian, J.A., Romero, A., Novoa, B., Figueras, A., Britton, W.J., de Silva, K., Purdie, A.C., Oehlers, S.H. (2018) Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility. Fish & shellfish immunology. 83:238-242

M, R., Medina-Gali, ., Belló-Pérez, M., Martínez-López, A., Falcó, A., Ortega-Villaizan, M.M., Encinar, J.A., Novoa, B., Coll, J., Perez, L. (2018) Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response. Fish & shellfish immunology. 82:514-521

Álvarez-Rodríguez, M., Pereiro, P., Reyes-López, F.E., Tort, L., Figueras, A., Novoa, B. (2018) Analysis of the Long-Lived Responses Induced by Immunostimulants and Their Effects on a Viral Infection in Zebrafish (Danio rerio).. Frontiers in immunology. 9:1575

M Medina-Gali, R., Ortega-Villaizán, M.D.M., Mercado, L., Novoa, B., Coll, J., Perez, L. (2018) Beta-glucan enhances the response to SVCV infection in zebrafish. Developmental and comparative immunology. 84:307-314

Bello-Perez, M., Falco, A., Medina-Gali, R., Pereiro, P., Encinar, J.A., Novoa, B., Perez, L., Coll, J. (2017) Neutralization of viral infectivity by zebrafish c-reactive protein isoforms. Molecular immunology. 91:145-155

Pereiro, P., Forn-Cuní, G., Dios, S., Coll, J., Figueras, A., Novoa, B. (2017) Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish. Antiviral Research. 145:146-159

García-Valtanen, P., Martínez-López, A., López-Muñoz, A., Bello-Perez, M., Medina-Gali, R.M., Del Mar Ortega-Villaizán, M., Varela, M., Figueras, A., Mulero, V., Novoa, B., Estepa, A., Coll, J. (2017) Corrigendum: Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes. Frontiers in immunology. 8:668

Bello-Perez, M., Falco, A., Medina, R., Encinar, J.A., Novoa, B., Perez, L., Estepa, A., Coll, J. (2017) Structure and functionalities of the human c-reactive protein compared to the zebrafish multigene family of c-reactive-like proteins. Developmental and comparative immunology. 69:33-40

Varela, M., Figueras, A., Novoa, B. (2017) Modelling viral infections using zebrafish: Innate immune response and antiviral research. Antiviral Research. 139:59-68

García-Valtanen, P., Martínez-López, A., López-Muñoz, A., Bello-Perez, M., Medina-Gali, R.M., Ortega-Villaizán, M.D., Varela, M., Figueras, A., Mulero, V., Novoa, B., Estepa, A., Coll, J. (2017) Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes. Frontiers in immunology. 8:121

Forn-Cuní, G., Varela, M., Pereiro, P., Novoa, B., Figueras, A. (2017) Conserved gene regulation during acute inflammation between zebrafish and mammals. Scientific Reports. 7:41905

Romero, A., Saraceni, P.R., Merino, S., Figueras, A., Tomás, J.M., Novoa, B. (2016) The Animal Model Determines the Results of Aeromonas Virulence Factors.. Frontiers in microbiology. 7:1574

Saraceni, P.R., Romero, A., Figueras, A., Novoa, B. (2016) Establishment of Infection Models in Zebrafish Larvae (Danio rerio) to Study the Pathogenesis of Aeromonas hydrophila. Frontiers in microbiology. 7:1219

Varela, M., Forn-Cuní, G., Dios, S., Figueras, A., Novoa, B. (2016) Proinflammatory Caspase A Activation and an Antiviral State Are Induced by a Zebrafish Perforin after Possible Cellular and Functional Diversification from a Myeloid Ancestor. Journal of Innate Immunity. 8(1):43-56

Kavaliauskis, A., Arnemo, M., Kim, S.H., Ulanova, L., Speth, M., Novoa, B., Dios, S., Evensen, Ø., Griffiths, G.W., Gjøen, T. (2015) Use of Poly(I:C) Stabilized with Chitosan As a Vaccine-Adjuvant Against Viral Hemorrhagic Septicemia Virus Infection in Zebrafish. Zebrafish. 12(6):421-31

Pereiro, P., Varela, M., Diaz-Rosales, P., Romero, A., Dios, S., Figueras, A., Novoa, B. (2015) Zebrafish Nk-lysins: first insights about their cellular and functional diversification. Developmental and comparative immunology. 51(1):148-59

Forn-Cuní, G., Varela, M., Fernández, C.M., Figueras, A., Novoa, B. (2015) Liver immune responses to inflammatory stimuli in a diet-induced obesity model of zebrafish. The Journal of endocrinology. 224(2):159-70

Dios, S., Balseiro, P., Costa, M.M., Romero, A., Boltaña, S., Roher, N., Mackenzie, S., Figueras, A., Novoa, B. (2014) The Involvement of Cholesterol in Sepsis and Tolerance to Lipopolysaccharide Highlighted by the Transcriptome Analysis of Zebrafish (Danio rerio). Zebrafish. 11(5):421-33

Varela, M., Romero, A., Dios, S., van der Vaart, M., Figueras, A., Meijer, A.H., Novoa, B. (2014) Cellular Visualization of Macrophage Pyroptosis and Interleukin-1β Release in a Viral Hemorrhagic Infection in Zebrafish Larvae. Journal of virology. 88(20):12026-40

García-Valtanen, P., Ortega-Villaizán, M.D., Martínez-López, A., Medina-Gali, R., Pérez, L., Mackenzie, S., Figueras, A., Coll, J.M., Estepa, A. (2014) Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules. Autophagy. 10(9):1666-80

Varela, M., Diaz-Rosales, P., Pereiro, P., Forn-Cuní, G., Costa, M.M., Dios, S., Romero, A., Figueras, A., Novoa, B. (2014) Interferon-Induced Genes of the Expanded IFIT Family Show Conserved Antiviral Activities in Non-Mammalian Species. PLoS One. 9:e100015

Forn-Cuní, G., Reis, E.S., Dios, S., Posada, D., Lambris, J.D., Figueras, A., Novoa, B. (2014) The Evolution and Appearance of C3 Duplications in Fish Originate an Exclusive Teleost c3 Gene Form with Anti-Inflammatory Activity. PLoS One. 9:e99673

Costa, M.M., Saraceni, P.R., Forn-Cuní, G., Dios, S., Romero, A., Figueras, A., and Novoa, B. (2013) IL-22 is a key player in the regulation of inflammation in fish and involves innate immune cells and PI3K signaling. Developmental and comparative immunology. 41(4):746-755

Ceinos, R.M., Torres-Nuñez, E., Chamorro, R., Novoa, B., Figueras, A., Ruane, N.M., and Rotllant, J. (2013) Critical Role of the Matricellular Protein SPARC in Mediating Erythroid Progenitor Cell Development in Zebrafish. Cells, tissues, organs. 197(3):196-208

Varela, M., Dios, S., Novoa, B., and Figueras, A. (2012) Characterisation, expression and ontogeny of interleukin-6 and its receptors in zebrafish (Danio rerio). Developmental and comparative immunology. 37(1):97-106

Novoa, B., and Figueras, A. (2012) Zebrafish: model for the study of inflammation and the innate immune response to infectious diseases. Advances in experimental medicine and biology. 946:253-275

López-Muñoz, A., Sepulcre, M.P., Roca, F.J., Figueras, A., Meseguer, J., and Mulero, V. (2011) Evolutionary conserved pro-inflammatory and antigen presentation functions of zebrafish IFNγ revealed by transcriptomic and functional analysis. Molecular immunology. 48(9-10):1073-1083

Dios, S., Romero, A., Chamorro, R., Figueras, A., and Novoa, B. (2010) Effect Of The Temperature During Antiviral Immune Response Ontogeny In Teleosts. Fish & shellfish immunology. 29(6):1019-1027

Monroig, O., Rotllant, J., Cerda-Reverter, J.M., Dick, J.R., Figueras, A., and Tocher, D.R. (2010) Expression and role of Elovl4 elongases in biosynthesis of very long-chain fatty acids during zebrafish Danio rerio early embryonic development. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1801(10):1145-1154

Encinas, P., Rodriguez-Milla, M.A., Novoa, B., Estepa, A., Figueras, A., and Coll, J. (2010) Zebrafish fin immune responses during high mortality infections with viral haemorrhagic septicemia rhabdovirus. A proteomic and transcriptomic approach. BMC Genomics. 11:518

Novoa, B., Mackenzie, S., and Figueras, A. (2010) Inflammation and Innate Immune Response Against Viral Infections in Marine Fish. Current pharmaceutical design. 16(38):4175-4184

Rodríguez, I., Chamorro, R., Novoa, B., and Figueras, A. (2009) beta-Glucan administration enhances disease resistance and some innate immune responses in zebrafish (Danio rerio). Fish & shellfish immunology. 27(2):369-373

Novoa, B., Bowman, T.V., Zon, L., and Figueras, A. (2009) LPS response and tolerance in the zebrafish (Danio rerio). Fish & shellfish immunology. 26(2):326-331

Rodríguez, I., Novoa, B., and Figueras, A. (2008) Immune response of zebrafish (Danio rerio) against a newly isolated bacterial pathogen Aeromonas hydrophila. Fish & shellfish immunology. 25(3):239-249

Novoa, B., Romero, A., Mulero, V., Rodriguez, I., Fernandez, I., and Figueras, A. (2006) Zebrafish (Danio rerio) as a model for the study of vaccination against viral haemorrhagic septicemia virus (VHSV). Vaccine. 24(31-31):5806-5816