ZFIN ID: ZDB-LAB-190326-1
Neurochemistry and Molecular Neuroscience
PI/Director: González Nuñez, Veronica
Contact Person: González Nuñez, Veronica
Email: vgnunez@usal.es
URL: http://diarium.usal.es/vgnunez/
Address: Lab 3. Instituto de Neurociencias de Castilla y León (INCYL) c/ Pintor Fernando Gallego, n. 1 37003 Salamanca
Country: Spain
Phone: +34 923294500 ext. 5337
Fax: +34 923294550
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
Subjects: Biochemistry & Molecular Biology; Developmental Biology; Neuroscience
Category (UNESCO nomenclature): 249002 Neurochemistry
Keywords:
- Neurotransmitters. Opioid System. Receptors and Peptides. Pain.
- Dopaminergic System. Addiction. Tolerance and Dependence. Reward pathway.
- In vivo testing of chemical compounds.


LAB MEMBERS
Calderón García, Andrés Ángel Graduate Student Bueno Montero, María José Research Staff Pérez Fernández, María Research Staff
Cabeza Paniagua, Manuel Curto Aguilera, Danie


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Rosa, M., Gonzalez-Nunez, V., Barreto-Valer, K., Marcelo, F., Sánchez-Sánchez, J., Calle, L.P., Arévalo, J.C., Rodríguez, R.E., Jiménez-Barbero, J., Arsequell, G., Valencia, G. (2017) Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides. Bioorganic & Medicinal Chemistry. 25(7):2260-2265
Jimenez-Gonzalez, A., García-Concejo, A., López-Benito, S., Gonzalez-Nunez, V., Arévalo, J.C., Rodriguez, R.E. (2016) Role of morphine, miR-212/132 and mu opioid receptor in the regulation of bdnf in zebrafish embryos. Biochimica et biophysica acta. General subjects. 1860(6):1308-16
Gonzalez-Nunez, V. (2015) Role of gabra2, GABAA receptor alpha-2 subunit, in CNS development.. Biochemistry and biophysics reports. 3:190-201
Gonzalez-Nunez, V., González, A.J., Barreto-Valer, K., and Rodríguez, R.E. (2013) In vivo regulation of the mu opioid receptor. Role of the endogenous opioid agents. Molecular medicine (Cambridge, Mass.). 19:7-17
Arsequell, G., Rosa, M., Mayato, C., Dorta, R.L., Gonzalez-Nunez, V., Barreto-Valer, K., Marcelo, F., Calle, L.P., Vázquez, J.T., Rodríguez, R.E., Jiménez-Barbero, J., and Valencia, G. (2011) Synthesis, biological evaluation and structural characterization of novel glycopeptide analogues of nociceptin N/OFQ. Organic & biomolecular chemistry. 9(17):6133-42
Rivas-Boyero, A.A., Herrero-Turrion, M.J., Gonzalez-Nunez, V., Sanchez-Simon, F.M., Barreto-Valer, K., and Rodriguez, R.E. (2011) Pharmacological characterization of a nociceptin receptor from zebrafish (Danio rerio). Journal of molecular endocrinology. 46(2):111-123
Gonzalez-Nunez, V., Nocco, V., and Budd, A. (2010) Characterization of drCol 15a1b: A Novel Component of the Stem Cell Niche in the Zebrafish Retina. Stem cells (Dayton, Ohio). 28(8):1399-1411
Gonzalez-Nunez, V., and Rodríguez, R.E. (2009) The zebrafish: a model to study the endogenous mechanisms of pain. ILAR journal. 50(4):373-386
Gonzalez-Nuñez, V., Toth, G., and Rodríguez, R.E. (2007) Endogenous heptapeptide Met-enkephalin-Gly-Tyr binds differentially to duplicate delta opioid receptors from zebrafish. Peptides. 28(12):2340-2347
Gonzalez-Nunez, V., Marron Fernandez de Velasco, E., Arsequell, G., Valencia, G.,and Rodriguez, R.E. (2007) Identification of dynorphin a from zebrafish: a comparative study with mammalian dynorphin A. Neuroscience. 144(2):675-684
Pinal-Seoane, N., Martin, I.R., Gonzalez-Nunez, V., de Velasco, E.M., Alvarez, F.A., Sarmiento, R.G., and Rodriguez, R.E. (2006) Characterization of a new duplicate {delta}-opioid receptor from zebrafish. Journal of molecular endocrinology. 37(3):391-403
Alvarez, F.A., Rodriguez-Martin, I., Gonzalez-Nuñez, V., de Velasco, E.M., Gonzalez Sarmiento, R., and Rodriguez, R.E. (2006) New kappa opioid receptor from zebrafish Danio rerio. Neuroscience letters. 405(1-2):94-99
Gonzalez-Nuñez, V., Barrallo, A., Traynor, J.R., and Rodriguez, R.E. (2006) Characterization of Opioid-Binding Sites in Zebrafish Brain. The Journal of pharmacology and experimental therapeutics. 316(2):900-904
Gonzalez-Nuñez, V., Arsequell, G., Szemenyei, E., Toth, G., Valencia, G., and Rodriguez, R.E. (2005) Binding profile of the endogenous novel heptapeptide met-enkephalin-gly-tyr in zebrafish and rat brain. The Journal of pharmacology and experimental therapeutics. 314(2):862-867
Gonzalez-Nuñez, V., Gonzalez-Sarmiento, R., and Rodriguez, R.E. (2003) Identification of two proopiomelanocortin genes in zebrafish (Danio rerio). Brain research. Molecular brain research. 120(1):1-8
Gonzalez-Nuñez, V., Gonzalez-Sarmiento, R., and Rodriguez, R.E. (2003) Cloning and characterization of a full-length pronociceptin in zebrafish: evidence of the existence of two different nociceptin sequences in the same precursor. BBA Gene Structure and Expression. 1629(1-3):114-118
González Nuñez, V., González Sarmiento, R., and Rodriguez, R.E. (2003) Characterization of zebrafish proenkephalin reveals novel opioid sequences. Mol. Brain Res.. 114(1):31-39
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