ZFIN Lab: Brooks Lab

ZFIN ID: ZDB-LAB-150911-2

Brooks Lab

PI/Director:	Brooks, Brian P.
Contact Person:	Brooks, Brian P.
Email:	brooksb@nei.nih.gov
URL:
Address:	10 Center Dr Building 10, Room 10N226, MSC1860 Bethesda, MD 20892
Country:	United States
Phone:	(301) 451-2238
Fax:
Line Designation:	nni

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 1 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Dutta, Sunit Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

George, A., Lee, J., Liu, J., Kim, S., Brooks, B.P. (2022) Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(4):495-509

Boobalan, E., Thompson, A.H., Alur, R.P., McGaughey, D.M., Dong, L., Shih, G., Vieta-Ferrer, E.R., Onojafe, I.F., Kalaskar, V.K., Arno, G., Lotery, A.J., Guan, B., Bender, C., Memon, O., Brinster, L., Soleilhavoup, C., Panman, L., Badea, T.C., Minella, A., Lopez, A.J., Thomasy, S.M., Moshiri, A., Blain, D., Hufnagel, R.B., Cogliati, T., Bharti, K., Brooks, B.P. (2022) Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure. Investigative ophthalmology & visual science. 63:5

Owen, N., Toms, M., Young, R.M., Eintracht, J., Sarkar, H., Brooks, B.P., Moosajee, M., Genomics England Research Consortium (2022) Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. Genetics in medicine : official journal of the American College of Medical Genetics. 24(5):1073-1084

Sloan, J.L., Achilly, N.P., Arnold, M.L., Catlett, J.L., Blake, T., Bishop, K., Jones, M., Harper, U., English, M.A., Anderson, S., Trivedi, N.S., Elkahloun, A., Hoffmann, V., Brooks, B.P., Sood, R., Venditti, C.P. (2020) The vitamin B12 processing enzyme, mmachc, is essential for zebrafish survival, growth and retinal morphology. Human molecular genetics. 29(13):2109-2123

George, A., Cogliati, T., Brooks, B.P. (2020) Genetics of syndromic ocular coloboma: CHARGE and COACH syndromes. Experimental Eye Research. 193:107940

Kalaskar, V.K., Alur, R.P., Li, L.K., Thomas, J.W., Sergeev, Y.V., Blain, D., Hufnagel, R.B., Cogliati, T., Brooks, B.P. (2019) High-throughput custom capture sequencing identifies novel mutations in coloboma-associated genes: Mutation in DNA-binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma. Human Mutation. 41(3):678-695

Hardy, H., Prendergast, J.G., Patel, A., Dutta, S., Trejo-Reveles, V., Kroeger, H., Yung, A.R., Goodrich, L.V., Brooks, B., Sowden, J.C., Rainger, J. (2019) Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion. eLIFE. 8:

Lahrouchi, N., George, A., Ratbi, I., Schneider, R., Elalaoui, S.C., Moosa, S., Bharti, S., Sharma, R., Abu-Asab, M., Onojafe, F., Adadi, N., Lodder, E.M., Laarabi, F.Z., Lamsyah, Y., Elorch, H., Chebbar, I., Postma, A.V., Lougaris, V., Plebani, A., Altmueller, J., Kyrieleis, H., Meiner, V., McNeill, H., Bharti, K., Lyonnet, S., Wollnik, B., Henrion-Caude, A., Berraho, A., Hildebrandt, F., Bezzina, C.R., Brooks, B.P., Sefiani, A. (2019) Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly. Nature communications. 10:1180

Louis, L.K., Gopurappilly, R., Surendran, H., Dutta, S., Pal, R. (2017) Transcriptional profiling of human neural precursors post alcohol exposure reveals impaired neurogenesis via dysregulation of ERK signaling and miR-145. Journal of neurochemistry.

George, A., Zand, D.J., Hufnagel, R.B., Sharma, R., Sergeev, Y.V., Legare, J.M., Rice, G.M., Scott Schwoerer, J.A., Rius, M., Tetri, L., Gamm, D.M., Bharti, K., Brooks, B.P. (2016) Biallelic Mutations in MITF Cause Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, and Deafness. American journal of human genetics. 99:1388-1394

Liu, C., Widen, S.A., Williamson, K.A., Ratnapriya, R., Gerth-Kahlert, C., Rainger, J., Alur, R.P., Strachan, E., Manjunath, S.H., Balakrishnan, A., Floyd, J.A., Li, T., Waskiewicz, A., Brooks, B.P., Lehmann, O.J., FitzPatrick, D.R., Swaroop, A. (2016) A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma. Human molecular genetics. 25(7):1382-91

Banerjee, P., Dutta, S., Pal, R. (2016) Dysregulation of Wnt-signaling and a candidate set of miRNAs underlie the effect of metformin on neural crest cell development. Stem cells (Dayton, Ohio). 34(2):334-45

Dutta, S., Sriskanda, S., Boobalan, E., Alur, R.P., Elkahloun, A., Brooks, B.P. (2015) nlz1 Is required for cilia formation in zebrafish embryogenesis. Developmental Biology. 406(2):203-11

Marchegiani, S., Davis, T., Tessadori, F., van Haaften, G., Brancati, F., Hoischen, A., Huang, H., Valkanas, E., Pusey, B., Schanze, D., Venselaar, H., Vulto-van Silfhout, A.T., Wolfe, L.A., Tifft, C.J., Zerfas, P.M., Zambruno, G., Kariminejad, A., Sabbagh-Kermani, F., Lee, J., Tsokos, M.G., Lee, C.R., Ferraz, V., da Silva, E.M., Stevens, C.A., Roche, N., Bartsch, O., Farndon, P., Bermejo-Sanchez, E., Brooks, B.P., Maduro, V., Dallapiccola, B., Ramos, F.J., Chung, H.B., Le Caignec, C., Martins, F., Jacyk, W.K., Mazzanti, L., Brunner, H.G., Bakkers, J., Lin, S., Malicdan, M.C., Boerkoel, C.F., Gahl, W.A., de Vries, B.B., van Haelst, M.M., Zenker, M., Markello, T.C. (2015) Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes. American journal of human genetics. 97(1):99-110

Babcock, H.E., Dutta, S., Alur, R.P., Brocker, C., Vasiliou, V., Vitale, S., Abu-Asab, M., Brooks, B.P. (2014) aldh7a1 Regulates Eye and Limb Development in Zebrafish. PLoS One. 9:e101782

Dutta, S., and Dawid, I.B. (2010) Kctd15 inhibits neural crest formation by attenuating Wnt/β-catenin signaling output. Development (Cambridge, England). 137(18):3013-3018

Brown, J.D., Dutta, S., Bharti, K., Bonner, R.F., Munson, P.J., Dawid, I.B., Akhtar, A.L., Onojafe, I.F., Alur, R.P., Gross, J.M., Hejtmancik, J.F., Jiao, X., Chan, W.Y., and Brooks, B.P. (2009) Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure. Proceedings of the National Academy of Sciences of the United States of America. 106(5):1462-1467

Dutta, S., Dietrich, J.E., Westerfield, M., and Varga, Z.M. (2008) Notch signaling regulates endocrine cell specification in the zebrafish anterior pituitary. Developmental Biology. 319(2):248-257

Dutta, S., Dietrich, J.E., Aspock, G., Burdine, R.D., Schier, A., Westerfield, M., and Varga, Z.M. (2005) pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development (Cambridge, England). 132(7):1579-1590

Dutta, S. (2005) Long-range and short-range signals play a role in Zebrafish (Danio rerio) anterior pituitary tissue and cell type specification. Ph.D. Thesis. :133p