ZFIN Person: Brooks, Brian P.

ZFIN ID: ZDB-PERS-150911-3

ZFIN ID: ZDB-PERS-150911-3

Brooks, Brian P.

Email:	brooksb@nei.nih.gov
URL:	https://nei.nih.gov/intramural/pediatric
Affiliation:	Brooks Lab
Address:	10 Center Dr Building 10, Room 10N226, MSC1860 Bethesda, MD 20892
Country:	United States
Phone:	(301) 451-2238
Fax:	301-402-1214
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

The genetics of eye development with the zebrafish as a model system.

PUBLICATIONS

George, A., Lee, J., Liu, J., Kim, S., Brooks, B.P. (2022) Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(4):495-509

Boobalan, E., Thompson, A.H., Alur, R.P., McGaughey, D.M., Dong, L., Shih, G., Vieta-Ferrer, E.R., Onojafe, I.F., Kalaskar, V.K., Arno, G., Lotery, A.J., Guan, B., Bender, C., Memon, O., Brinster, L., Soleilhavoup, C., Panman, L., Badea, T.C., Minella, A., Lopez, A.J., Thomasy, S.M., Moshiri, A., Blain, D., Hufnagel, R.B., Cogliati, T., Bharti, K., Brooks, B.P. (2022) Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure. Investigative ophthalmology & visual science. 63:5

Owen, N., Toms, M., Young, R.M., Eintracht, J., Sarkar, H., Brooks, B.P., Moosajee, M., Genomics England Research Consortium (2022) Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. Genetics in medicine : official journal of the American College of Medical Genetics. 24(5):1073-1084

Sloan, J.L., Achilly, N.P., Arnold, M.L., Catlett, J.L., Blake, T., Bishop, K., Jones, M., Harper, U., English, M.A., Anderson, S., Trivedi, N.S., Elkahloun, A., Hoffmann, V., Brooks, B.P., Sood, R., Venditti, C.P. (2020) The vitamin B12 processing enzyme, mmachc, is essential for zebrafish survival, growth and retinal morphology. Human molecular genetics. 29(13):2109-2123

George, A., Cogliati, T., Brooks, B.P. (2020) Genetics of syndromic ocular coloboma: CHARGE and COACH syndromes. Experimental Eye Research. 193:107940

Kalaskar, V.K., Alur, R.P., Li, L.K., Thomas, J.W., Sergeev, Y.V., Blain, D., Hufnagel, R.B., Cogliati, T., Brooks, B.P. (2019) High-throughput custom capture sequencing identifies novel mutations in coloboma-associated genes: Mutation in DNA-binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma. Human Mutation. 41(3):678-695

Hardy, H., Prendergast, J.G., Patel, A., Dutta, S., Trejo-Reveles, V., Kroeger, H., Yung, A.R., Goodrich, L.V., Brooks, B., Sowden, J.C., Rainger, J. (2019) Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion. eLIFE. 8:

Lahrouchi, N., George, A., Ratbi, I., Schneider, R., Elalaoui, S.C., Moosa, S., Bharti, S., Sharma, R., Abu-Asab, M., Onojafe, F., Adadi, N., Lodder, E.M., Laarabi, F.Z., Lamsyah, Y., Elorch, H., Chebbar, I., Postma, A.V., Lougaris, V., Plebani, A., Altmueller, J., Kyrieleis, H., Meiner, V., McNeill, H., Bharti, K., Lyonnet, S., Wollnik, B., Henrion-Caude, A., Berraho, A., Hildebrandt, F., Bezzina, C.R., Brooks, B.P., Sefiani, A. (2019) Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly. Nature communications. 10:1180

George, A., Zand, D.J., Hufnagel, R.B., Sharma, R., Sergeev, Y.V., Legare, J.M., Rice, G.M., Scott Schwoerer, J.A., Rius, M., Tetri, L., Gamm, D.M., Bharti, K., Brooks, B.P. (2016) Biallelic Mutations in MITF Cause Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, and Deafness. American journal of human genetics. 99:1388-1394

Liu, C., Widen, S.A., Williamson, K.A., Ratnapriya, R., Gerth-Kahlert, C., Rainger, J., Alur, R.P., Strachan, E., Manjunath, S.H., Balakrishnan, A., Floyd, J.A., Li, T., Waskiewicz, A., Brooks, B.P., Lehmann, O.J., FitzPatrick, D.R., Swaroop, A. (2016) A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma. Human molecular genetics. 25(7):1382-91

Dutta, S., Sriskanda, S., Boobalan, E., Alur, R.P., Elkahloun, A., Brooks, B.P. (2015) nlz1 Is required for cilia formation in zebrafish embryogenesis. Developmental Biology. 406(2):203-11

Marchegiani, S., Davis, T., Tessadori, F., van Haaften, G., Brancati, F., Hoischen, A., Huang, H., Valkanas, E., Pusey, B., Schanze, D., Venselaar, H., Vulto-van Silfhout, A.T., Wolfe, L.A., Tifft, C.J., Zerfas, P.M., Zambruno, G., Kariminejad, A., Sabbagh-Kermani, F., Lee, J., Tsokos, M.G., Lee, C.R., Ferraz, V., da Silva, E.M., Stevens, C.A., Roche, N., Bartsch, O., Farndon, P., Bermejo-Sanchez, E., Brooks, B.P., Maduro, V., Dallapiccola, B., Ramos, F.J., Chung, H.B., Le Caignec, C., Martins, F., Jacyk, W.K., Mazzanti, L., Brunner, H.G., Bakkers, J., Lin, S., Malicdan, M.C., Boerkoel, C.F., Gahl, W.A., de Vries, B.B., van Haelst, M.M., Zenker, M., Markello, T.C. (2015) Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes. American journal of human genetics. 97(1):99-110

Babcock, H.E., Dutta, S., Alur, R.P., Brocker, C., Vasiliou, V., Vitale, S., Abu-Asab, M., Brooks, B.P. (2014) aldh7a1 Regulates Eye and Limb Development in Zebrafish. PLoS One. 9:e101782

Brown, J.D., Dutta, S., Bharti, K., Bonner, R.F., Munson, P.J., Dawid, I.B., Akhtar, A.L., Onojafe, I.F., Alur, R.P., Gross, J.M., Hejtmancik, J.F., Jiao, X., Chan, W.Y., and Brooks, B.P. (2009) Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure. Proceedings of the National Academy of Sciences of the United States of America. 106(5):1462-1467

NON-ZEBRAFISH PUBLICATIONS
Alur RP, Camasamudram V, Brown JD, Mehtani M, Onojafe IF, Sergeev YV, Boobalan E, Jone MP, Tang K, Liu H, Chun-hong X, Gong X, Brooks BP. Papillorenal syndrome-causing missense mutations in PAX2/Pax2 result in hypomorphic alleles in mouse and human. PloS Genet. 6(3):e1000870. (2010) PMCID: PMC2832668

Onojafe IF, Adams DR, Simeonov DR, Zhang J, Chan CC, Bernardini IM, Sergeev YV, Dolinska MB, Alur RP, Brilliant MH, Gahl WA, Brooks BP. Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism. J Clin Invest. 121: 3914-23. (2011) PMCID: PMC3223618.