ZFIN Lab: Frazer Lab

ZFIN ID: ZDB-LAB-081125-1

Frazer Lab

PI/Director:	Frazer, Kimble
Contact Person:	Frazer, Kimble
Email:	Kimble-frazer@ouhsc.edu
URL:
Address:	Frazer Laboratory University of Oklahoma Health Sciences Center Basic Sciences Education Bldg., Rm. 229 Oklahoma City, OK 73104
Country:	United States
Phone:	405-271-5311 ext. 42375
Fax:	405-271-3767
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Our lab studies 2 related types of T cell cancer: T cell acute lymphoblastic leukemia (T-ALL) and T cell lymphoblastic lymphoma (T-LBL). We use several T cell cancer-prone genetic lines to investigate the genomic, genetic, and transcriptional events that underlie oncogenesis. We also pursue the molecular explanations for why some T cell cancers are more aggressive and/or drug-resistant than others. Finally, we use fish with active cancers to test candidate compounds in vivo, to see whether they might be effective medicines for the treatment of T cell malignancy.

LAB MEMBERS

Batchelor, Lance Research Staff	Squiban, Barbara Research Staff	Hawkins, Julie Technical Staff
Schatzman-Bone, Steph Technical Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Loontiens, S., Vanhauwaert, S., Depestel, L., Dewyn, G., Van Loocke, W., Moore, F.E., Garcia, E.G., Batchelor, L., Borga, C., Squiban, B., Malone-Perez, M., Volders, P.J., Olexiouk, V., Van Vlierberghe, P., Langenau, D.M., Frazer, J.K., Durinck, K., Speleman, F. (2020) A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models. Leukemia. 34(12):3398-3403

Sinha, A.A., Park, G., Frazer, J.K. (2019) Tackling Acute Lymphoblastic Leukemia-One Fish at a Time. International Journal of Molecular Sciences. 20(21):

Sanghera, D.K., Hopkins, R., Malone-Perez, M.W., Bejar, C., Tan, C., Mussa, H., Whitby, P., Fowler, B., Rao, C.V., Fung, K.A., Lightfoot, S., Frazer, J.K. (2019) Targeted sequencing of candidate genes of dyslipidemia in Punjabi Sikhs: Population-specific rare variants in GCKR promote ectopic fat deposition. PLoS One. 14:e0211661

Borga, C., Frazer, J.K. (2019) Zebrafish MYC-induced leukemia models: unique in vivo systems to study B and T cell acute lymphoblastic leukemia. International journal of hematologic oncology. 8:IJH12

Burroughs-Garcia, J., Hasan, A., Park, G., Borga, C., Frazer, J.K. (2019) Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish. Journal of visualized experiments : JoVE. (144):

Borga, C., Foster, C.A., Iyer, S., Garcia, S.P., Langenau, D.M., Frazer, J.K. (2018) Molecularly distinct models of zebrafish Myc-induced B cell leukemia. Leukemia. 33(2):559-562

Borga, C., Park, G., Foster, C., Burroughs-Garcia, J., Marchesin, M., Shah, R., Hasan, A., Ahmed, S.T., Bresolin, S., Batchelor, L., Scordino, T., Miles, R.R., Te Kronnie, G., Regens, J.L., Frazer, J.K. (2018) Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis. Leukemia. 33(2):333-347

Nissim, S., Weeksb, O., Talbot, J.C., Hedgepeth, J.W., Wucherpfennig, J., Schatzman-Bone, S., Swinburne, I., Cortes, M., Alexa, K., Megason, S., North, T.E., Amacher, S.L., Goessling, W. (2016) Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development. Developmental Biology. 418(1):108-23

Jain, I.H., Zazzeron, L., Goli, R., Alexa, K., Schatzman-Bone, S., Dhillon, H., Goldberger, O., Peng, J., Shalem, O., Sanjana, N.E., Zhang, F., Goessling, W., Zapol, W.M., Mootha, V.K. (2016) Hypoxia as a therapy for mitochondrial disease. Science (New York, N.Y.). 352(6281):54-61

Liu, L.Y., Alexa, K., Cortes, M., Schatzman-Bone, S., Kim, A.J., Mukhopadhyay, B., Cinar, R., Kunos, G., North, T.E., Goessling, W. (2016) Cannabinoid receptor signaling regulates liver development and metabolism. Development (Cambridge, England). 143:609-22

Squiban, B., Frazer, J.K. (2014) Danio rerio: Small Fish Making a Big Splash in Leukemia.. Current pathobiology reports. 2:61-73

West, K., Miles, R., Kent, M.L., Frazer, J.K. (2014) Unusual Fluorescent Granulomas and Myonecrosis in Danio Rerio Infected by the Microsporidian Pathogen Pseudoloma Neurophilia. Zebrafish. 11(3):283-90

Christoph, S., Deryckere, D., Schlegel, J., Frazer, J.K., Batchelor, L.A., Trakhimets, A.Y., Sather, S., Hunter, D.M., Cummings, C., Liu, J., Yang, C., Kireev, D., Simpson, C., Norris-Drouin, J., Hull-Ryde, E.A., Janzen, W.P., Johnson, G.L., Wang, X., Frye, S.V., Earp, H.S., and Graham, D.K. (2013) UNC569, a novel small molecule Mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Molecular cancer therapeutics. 12(11):2367-77

Ridges, S., Heaton, W.L., Joshi, D., Choi, H., Eiring, A., Batchelor, L., Choudhry, P., Manos, E.J, Sofla, H., Sanati, A., Welborn, S., Agarwal, A., Spangrude, G.J., Miles, R.R., Cox, J.E., Frazer, J.K., Deininger, M., Balan, K., Sigman, M., Müschen, M., Perova, T., Johnson, R., Montpellier, B., Guidos, C.J., Jones, D.A., and Trede, N.S. (2012) Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood. 119(24):5621-5631

Frazer, J.K., Batchelor, L.A., Bradley, D.F., Brown, K.H., Dobrinski, K.P., Lee, C., and Trede, N.S. (2012) Genomic Amplification of an Endogenous Retrovirus in Zebrafish T-Cell Malignancies. Advances in hematology. 2012:627920

Rudner, L.A., Brown, K.H., Dobrinski, K.P., Bradley, D.F., Garcia, M.I., Smith, A.C., Downie, J.M., Meeker, N.D., Look, A.T., Downing, J.R., Gutierrez, A., Mullighan, C.G., Schiffman, J.D., Lee, C., Trede, N.S., and Frazer, J.K. (2011) Shared acquired genomic changes in zebrafish and human T-ALL. Oncogene. 30(41):4289-96

Meeker, N.D., Smith, A.C., Frazer, J.K., Bradley, D.F., Rudner, L.A., Love, C., and Trede, N.S. (2010) Characterization of the zebrafish T cell receptor beta locus. Immunogenetics. 62(1):23-29

Frazer, J.K., Meeker, N.D., Rudner, L., Bradley, D.F., Smith, A.C., Demarest, B., Joshi, D., Locke, E.E., Hutchinson, S.A., Tripp, S., Perkins, S.L., and Trede, N.S. (2009) Heritable T-cell malignancy models established in a zebrafish phenotypic screen. Leukemia. 23(10):1825-1835

Rudner, L.A., Frazer, J.K., and Trede, N.S. (2009) Modeling human hematologic malignancies in zebrafish: A review. Current Trends in Immunology. 10:119-124