ZFIN Person: Frazer, Kimble

ZFIN ID: ZDB-PERS-091214-14

ZFIN ID: ZDB-PERS-091214-14

Frazer, Kimble

Email:	Kimble-Frazer@ouhsc.edu
URL:
Affiliation:	Frazer Lab
Address:	University of Oklahoma Health Sciences Center Basic Sciences Education Bldg., Rm. 224 Oklahoma City, OK 73104 USA
Country:	United States
Phone:	405-271-5311
Fax:	405-271-3767
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

I am a pediatric hematologist-oncologist and physician-scientist. I did MD/PhD training at UT Southwestern & the OU College of Medicine. I then completed a residency in General Pediatrics and a fellowship in Pediatric Heme/Onc at the University of Utah. I was a member of the U of U faculty for 5 years, and am moving to the University of Oklahoma Health Sciences Center to start my own laboratory in summer 2012.

PUBLICATIONS

Loontiens, S., Vanhauwaert, S., Depestel, L., Dewyn, G., Van Loocke, W., Moore, F.E., Garcia, E.G., Batchelor, L., Borga, C., Squiban, B., Malone-Perez, M., Volders, P.J., Olexiouk, V., Van Vlierberghe, P., Langenau, D.M., Frazer, J.K., Durinck, K., Speleman, F. (2020) A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models. Leukemia. 34(12):3398-3403

Sinha, A.A., Park, G., Frazer, J.K. (2019) Tackling Acute Lymphoblastic Leukemia-One Fish at a Time. International Journal of Molecular Sciences. 20(21):

Sanghera, D.K., Hopkins, R., Malone-Perez, M.W., Bejar, C., Tan, C., Mussa, H., Whitby, P., Fowler, B., Rao, C.V., Fung, K.A., Lightfoot, S., Frazer, J.K. (2019) Targeted sequencing of candidate genes of dyslipidemia in Punjabi Sikhs: Population-specific rare variants in GCKR promote ectopic fat deposition. PLoS One. 14:e0211661

Borga, C., Frazer, J.K. (2019) Zebrafish MYC-induced leukemia models: unique in vivo systems to study B and T cell acute lymphoblastic leukemia. International journal of hematologic oncology. 8:IJH12

Burroughs-Garcia, J., Hasan, A., Park, G., Borga, C., Frazer, J.K. (2019) Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish. Journal of visualized experiments : JoVE. (144):

Borga, C., Foster, C.A., Iyer, S., Garcia, S.P., Langenau, D.M., Frazer, J.K. (2018) Molecularly distinct models of zebrafish Myc-induced B cell leukemia. Leukemia. 33(2):559-562

Borga, C., Park, G., Foster, C., Burroughs-Garcia, J., Marchesin, M., Shah, R., Hasan, A., Ahmed, S.T., Bresolin, S., Batchelor, L., Scordino, T., Miles, R.R., Te Kronnie, G., Regens, J.L., Frazer, J.K. (2018) Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis. Leukemia. 33(2):333-347

Squiban, B., Frazer, J.K. (2014) Danio rerio: Small Fish Making a Big Splash in Leukemia.. Current pathobiology reports. 2:61-73

West, K., Miles, R., Kent, M.L., Frazer, J.K. (2014) Unusual Fluorescent Granulomas and Myonecrosis in Danio Rerio Infected by the Microsporidian Pathogen Pseudoloma Neurophilia. Zebrafish. 11(3):283-90

Ridges, S., Heaton, W.L., Joshi, D., Choi, H., Eiring, A., Batchelor, L., Choudhry, P., Manos, E.J, Sofla, H., Sanati, A., Welborn, S., Agarwal, A., Spangrude, G.J., Miles, R.R., Cox, J.E., Frazer, J.K., Deininger, M., Balan, K., Sigman, M., Müschen, M., Perova, T., Johnson, R., Montpellier, B., Guidos, C.J., Jones, D.A., and Trede, N.S. (2012) Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood. 119(24):5621-5631

Frazer, J.K., Batchelor, L.A., Bradley, D.F., Brown, K.H., Dobrinski, K.P., Lee, C., and Trede, N.S. (2012) Genomic Amplification of an Endogenous Retrovirus in Zebrafish T-Cell Malignancies. Advances in hematology. 2012:627920

Rudner, L.A., Brown, K.H., Dobrinski, K.P., Bradley, D.F., Garcia, M.I., Smith, A.C., Downie, J.M., Meeker, N.D., Look, A.T., Downing, J.R., Gutierrez, A., Mullighan, C.G., Schiffman, J.D., Lee, C., Trede, N.S., and Frazer, J.K. (2011) Shared acquired genomic changes in zebrafish and human T-ALL. Oncogene. 30(41):4289-96

Meeker, N.D., Smith, A.C., Frazer, J.K., Bradley, D.F., Rudner, L.A., Love, C., and Trede, N.S. (2010) Characterization of the zebrafish T cell receptor beta locus. Immunogenetics. 62(1):23-29

Frazer, J.K., Meeker, N.D., Rudner, L., Bradley, D.F., Smith, A.C., Demarest, B., Joshi, D., Locke, E.E., Hutchinson, S.A., Tripp, S., Perkins, S.L., and Trede, N.S. (2009) Heritable T-cell malignancy models established in a zebrafish phenotypic screen. Leukemia. 23(10):1825-1835

Rudner, L.A., Frazer, J.K., and Trede, N.S. (2009) Modeling human hematologic malignancies in zebrafish: A review. Current Trends in Immunology. 10:119-124

NON-ZEBRAFISH PUBLICATIONS
El-Mallawany NK, Frazer JK, Van Vlierberghe PV, Ferrando AA, Perkins S, Lim M, Chu Y, Cairo MS. Pediatric T- and NK-Cell lymphomas: new biologic insights and treatment strategies. (In press, Blood Cancer Journal, 2012).

Meeker ND, Cherry AM, Bangs CD, Frazer JK. (2011). A pediatric B lineage leukemia with coincident MYC and MLL translocations. J Pediatr Hematol Oncol. 33:158-60.

South ST, Frazer JK, Brothman A, Chen Z. (2006). Unexpected cytogenetic finding in acute lymphoblastic leukemia: a case of del(5q) with a cryptic t(12;21). Cancer Genet and Cytogenet. 168:177-8.

Bonkowsky JL, Frazer JK, Buchi KF, Byington CL. (2002). Metamizole use by Latino immigrants: a common and potentially harmful home remedy. Pediatrics. 109:e98.

Frazer JK, Jackson DG, Gaillard JP, Lutter M, Liu YJ, Banchereau J, Capra JD, Pascual V. (2000). Identification of centerin: a novel human germinal center B cell-restricted serpin. Eur J Immunol. 30:3039-48.

Yun TJ, Chaudhary PM, Shu GL, Frazer JK, Ewings MK, Schwartz SM, Pascual V, Hood LE, Clark EA. (1998). OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40. J Immunol. 161:6113-21.

Frazer JK, Pascual V, Capra JD. (1997). RDA of lymphocyte subsets. J Immunol Methods. 207:1-12.

Frazer JK, LeGros J, de Bouteiller O, Liu YJ, Banchereau J, Pascual V, Capra JD. (1997). Identification and cloning of genes expressed by human tonsillar B lymphocyte subsets. Ann N Y Acad Sci. 815:316-8.