KOM70144

Term ID

CHEBI:167314

Synonyms

(R)-5-acetamido-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide
5-(acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide
5-acetamido-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide
5-N-acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide

Definition

A benzamide that is GRL-0617 in which one of the hydrogen's of the primary amino group is replaced by an acetyl group. It an inhibitor of SARS-CoV and SARS-CoV-2 papain-like protease (PLpro) with an IC50 of 2.6 muM and 5.0 muM, respectively. It also inhibits SARS-CoV and SARS-CoV-2 infection of Vero E6 cells in vitro (EC50 values are 13.1 and 21 muM, respectively).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: acetamides benzamides naphthalenes secondary carboxamide

acetamides benzamides naphthalenes secondary carboxamide Show first 5 Terms
has_functional_parent: GRL-0617

GRL-0617 Show first 5 Terms
has_role: anticoronaviral agent protease inhibitor

anticoronaviral agent protease inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from KOM70144

Phenotype where environments contain KOM70144

Phenotype modified by environments containing KOM70144

Human Disease / Model Data

Citations