Aspatwar, A., Hammarén, M., Koskinen, S., Luukinen, B., Barker, H., Carta, F., Supuran, C.T., Parikka, M., Parkkila, S. (2017) β-CA-specific inhibitor dithiocarbamate Fc14-584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis. Journal of enzyme inhibition and medicinal chemistry. 32:832-840
|
Ates, L.S., van der Woude, A.D., Bestebroer, J., van Stempvoort, G., Musters, R.J., Garcia-Vallejo, J.J., Picavet, D.I., Weerd, R.V., Maletta, M., Kuijl, C.P., van der Wel, N.N., Bitter, W. (2016) The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10. PLoS pathogens. 12:e1005696
|
Batalha, I.L., Bernut, A., Schiebler, M., Ouberai, M.M., Passemar, C., Klapholz, C., Kinna, S., Michel, S., Sader, K., Castro-Hartmann, P., Renshaw, S.A., Welland, M.E., Andres Floto, R. (2019) Polymeric nanobiotics as a novel treatment for mycobacterial infections. Journal of controlled release : official journal of the Controlled Release Society. 314:116-124
|
Bobesh, K.A., Renuka, J., Srilakshmi, R.R., Yellanki, S., Kulkarni, P., Yogeeswari, P., Sriram, D. (2016) Replacement of cardiotoxic aminopiperidine linker with piperazine moiety reduces cardiotoxicity? Mycobacterium tuberculosis novel bacterial topoisomerase inhibitors. Bioorganic & Medicinal Chemistry. 24:42-52
|
Bruinen, A.L., Fisher, G.L., Balez, R., van der Sar, A.M., Ooi, L., Heeren, R.M.A. (2018) Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry. Journal of the American Society for Mass Spectrometry. 29(8):1571-1581
|
Burggraaf, M.J., Speer, A., Meijers, A.S., Ummels, R., van der Sar, A.M., Korotkov, K.V., Bitter, W., Kuijl, C. (2019) Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease. mBio. 10(5):
|
Cambier, C.J., Takaki, K.K., Larson, R.P., Hernandez, R.E., Tobin, D.M., Urdahl, K.B., Cosma, C.L., and Ramakrishnan, L. (2014) Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. Nature. 505(7482):218-222
|
Carvalho, R., de Sonneville, J., Stockhammer, O.W., Savage, N.D., Veneman, W.J., Ottenhoff, T.H., Dirks, R.P., Meijer, A.H., and Spaink, H.P. (2011) A high-throughput screen for tuberculosis progression. PLoS One. 6(2):e16779
|
Chen, C.C., Chen, Y.Y., Yeh, C.C., Hsu, C.W., Yu, S.J., Hsu, C.H., Wei, T.C., Ho, S.N., Tsai, P.C., Song, Y.D., Yen, H.J., Chen, X.A., Young, J.J., Chuang, C.C., Dou, H.Y. (2021) Alginate-Capped Silver Nanoparticles as a Potent Anti-mycobacterial Agent Against Mycobacterium tuberculosis. Frontiers in pharmacology. 12:746496
|
Chen, Z., Hu, Y., Cumming, B.M., Lu, P., Feng, L., Deng, J., Steyn, A.J., Chen, S. (2016) Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish. Cell Reports. 16(9):2512-24
|
Chen, Z., Shao, X.Y., Wang, C., Hua, M.H., Wang, C.N., Wang, X., Wang, Q.J., Yao, J.Y., Fan, Y.H., Qin, Y.W. (2018) Mycobacterium marinum Infection in Zebrafish and Microglia Imitates the Early Stage of Tuberculous Meningitis. Journal of molecular neuroscience : MN. 64(2):321-330
|
Commandeur, S., Iakobachvili, N., Sparrius, M., Nur, M.M., Mukamolova, G.V., Bitter, W. (2020) A zebrafish embryo model for assessment of drug efficacy on mycobacterial persisters. Antimicrobial Agents and Chemotherapy. 64(10):
|
Cronan, M.R., Beerman, R.W., Rosenberg, A.F., Saelens, J.W., Johnson, M.G., Oehlers, S.H., Sisk, D.M., Jurcic Smith, K.L., Medvitz, N.A., Miller, S.E., Trinh, L.A., Fraser, S.E., Madden, J.F., Turner, J., Stout, J.E., Lee, S., Tobin, D.M. (2016) Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection. Immunity. 45:861-876
|
Cronan, M.R., Hughes, E.J., Brewer, W.J., Viswanathan, G., Hunt, E.G., Singh, B., Mehra, S., Oehlers, S.H., Gregory, S.G., Kaushal, D., Tobin, D.M. (2021) A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization. Cell. 184(7):1757-1774.e14
|
Cui, J., Chen, G., Wen, D., Wang, Y., Zhao, Z., Wu, C. (2020) Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration. Frontiers in cellular and infection microbiology. 10:519503
|
Dal, N.K., Speth, M., Johann, K., Barz, M., Beauvineau, C., Wohlmann, J., Fenaroli, F., Gicquel, B., Griffiths, G., Alonso-Rodriguez, N. (2021) The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds. Disease models & mechanisms. 15(1):
|
Dam, S., Tangara, S., Hamela, C., Hattabi, T., Faïon, L., Carre, P., Antoine, R., Herledan, A., Leroux, F., Piveteau, C., Eveque, M., Flipo, M., Deprez, B., Kremer, L., Willand, N., Villemagne, B., Hartkoorn, R.C. (2022) Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases. Journal of medicinal chemistry. 65(24):16651-16664
|
Devi, P.B., Sridevi, J.P., Kakan, S.S., Saxena, S., Jeankumar, V.U., Soni, V., Anantaraju, H.S., Yogeeswari, P., Sriram, D. (2015) Discovery of novel lysine ɛ-aminotransferase inhibitors: An intriguing potential target for latent tuberculosis. Tuberculosis (Edinburgh, Scotland). 95:786-94
|
Ding, X., Wu, Y., Tong, A., Sun, B., Zhao, Y., Jiang, Y. (2020) Evaluation the anti-Mycobacterial activity of newly synthesized (S)-N-(3-(2-fluoro-4'-(2-amino-4-thiazolyl)biphenyl-4-yl)-2-oxo-1,3-oxazolidie-5-ylmethyl) acetamide derivative in vitro and in Mycobacterium marinum infected zebrafish. Japanese journal of infectious diseases. 74(3):245-248
|
Ding, Y., Raterink, R.J., Marín-Juez, R., Veneman, W.J., Egbers, K., van den Eeden, S., Haks, M.C., Joosten, S.A., Ottenhoff, T.H.M., Harms, A.C., Alia, A., Hankemeier, T., Spaink, H.P. (2020) Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae. Scientific Reports. 10:11635
|
Dong, W., Nie, X., Zhu, H., Liu, Q., Shi, K., You, L., Zhang, Y., Fan, H., Yan, B., Niu, C., Lyu, L.D., Zhao, G.P., Yang, C. (2021) Mycobacterial fatty acid catabolism is repressed by FdmR to sustain lipogenesis and virulence. Proceedings of the National Academy of Sciences of the United States of America. 118(16):
|
Feng, S., Hong, Z., Zhang, G., Li, J., Tian, G.B., Zhou, H., Huang, X. (2021) Mycobacterium PPE31 Contributes to Host Cell Death. Frontiers in cellular and infection microbiology. 11:629836
|
|
Harjula, S.E., Saralahti, A.K., Ojanen, M.J.T., Rantapero, T., Uusi-Mäkelä, M.I.E., Nykter, M., Lohi, O., Parikka, M., Rämet, M. (2019) Characterization of immune response against Mycobacterium marinum infection in the main hematopoietic organ of adult zebrafish (Danio rerio). Developmental and comparative immunology. 103:103523
|
Hawkins, P.M.E., Hoi, D.M., Cheung, C.Y., Wang, T., Quan, D., Sasi, V.M., Liu, D.Y., Linington, R.G., Jackson, C.J., Oehlers, S.H., Cook, G.M., Britton, W.J., Clausen, T., Payne, R.J. (2022) Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A. Journal of medicinal chemistry. 65(6):4893-4908
|
Ho, V.Q.T., Verboom, T., Rong, M.K., Habjan, E., Bitter, W., Speer, A. (2021) Heterologous expression of ethA and katG in Mycobacterium marinum enables the rapid identification of new prodrugs active against Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 65(4):
|
Hosseini, R., Lamers, G.E., Soltani, H.M., Meijer, A.H., Spaink, H.P., Schaaf, M.J. (2016) Efferocytosis and extrusion of leukocytes determine the progression of early mycobacterial pathogenesis. Journal of Cell Science. 129(18):3385-95
|
Hu, W., Yang, S., Shimada, Y., Münch, M., Marín-Juez, R., Meijer, A.H., Spaink, H.P. (2019) Infection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection. BMC Genomics. 20:878
|
Jeankumar, V.U., Kotagiri, S., Janupally, R., Suryadevara, P., Sridevi, J.P., Medishetti, R., Kulkarni, P., Yogeeswari, P., Sriram, D. (2015) Exploring the gyrase ATPase domain for tailoring newer anti-tubercular drugs: hit to lead optimization of a novel class of thiazole inhibitors. Bioorganic & Medicinal Chemistry. 23:588-601
|
Jeankumar, V.U., Reshma, R.S., Janupally, R., Saxena, S., Sridevi, J.P., Medapi, B., Kulkarni, P., Yogeeswari, P., Sriram, D. (2015) Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain: lead optimization and structure activity profiling. Organic & biomolecular chemistry. 13:2423-31
|
Johansen, M.D., Hortle, E., Kasparian, J.A., Romero, A., Novoa, B., Figueras, A., Britton, W.J., de Silva, K., Purdie, A.C., Oehlers, S.H. (2018) Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility. Fish & shellfish immunology. 83:238-242
|
Johansen, M.D., Kasparian, J.A., Hortle, E., Britton, W.J., Purdie, A.C., Oehlers, S.H. (2018) Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models. Developmental and comparative immunology. 88:169-172
|
Kan, Y., Meng, L., Xie, L., Liu, L., Dong, W., Feng, J., Yan, Y., Zhao, C., Peng, G., Wang, D., Lu, M., Yang, C., Niu, C. (2019) Temporal modulation of host aerobic glycolysis determines the outcome of Mycobacterium marinum infection. Fish & shellfish immunology. 96:78-85
|
Kenyon, A., Gavriouchkina, D., Zorman, J., Napolitani, G., Cerundolo, V., Sauka-Spengler, T. (2017) Active nuclear transcriptome analysis reveals inflammasome-dependent mechanism for early neutrophil response to Mycobacterium marinum. Scientific Reports. 7:6505
|
Levitte, S., Adams, K.N., Berg, R.D., Cosma, C.L., Urdahl, K.B., Ramakrishnan, L. (2016) Mycobacterial Acid Tolerance Enables Phagolysosomal Survival and Establishment of Tuberculous Infection In Vivo. Cell Host & Microbe. 20:250-258
|
Li, Y.Y., Liu, H.M., Wang, D., Lu, Y., Ding, C., Zhou, L.S., Wu, X.Y., Zhou, Z.W., Xu, S.Q., Lin, C., Qin, L.H., Li, Y., Liu, J., Liu, H.P., Zhang, L. (2022) Arabinogalactan enhances Mycobacterium marinum virulence by suppressing host innate immune responses. Frontiers in immunology. 13:879775
|
Lin, C., Tang, Y., Wang, Y., Zhang, J., Li, Y., Xu, S., Xia, B., Zhai, Q., Li, Y., Zhang, L., Liu, J. (2022) WhiB4 Is Required for the Reactivation of Persistent Infection of Mycobacterium marinum in Zebrafish. Microbiology spectrum. 10(2):e0044321
|
Liu, D.Q., Zhang, J.L., Pan, Z.F., Mai, J.T., Mei, H.J., Dai, Y., Zhang, L., Wang, Q.Z. (2019) Over-expression of Tgs1 in Mycobacterium marinum enhances virulence in adult zebrafish. International journal of medical microbiology : IJMM. 310(1):151378
|
|
Luukinen, H., Hammarén, M.M., Vanha-Aho, L.M., Svorjova, A., Kantanen, L., Järvinen, S., Luukinen, B.V., Dufour, E., Rämet, M., Hytönen, V.P., Parikka, M. (2017) Priming of innate antimycobacterial immunity by heat-killed Listeria monocytogenes induces sterilizing response in the adult zebrafish tuberculosis model.. Disease models & mechanisms. 11(1)
|
|
Malapati, P., Siva Krishna, V., Nallangi, R., Meda, N., Reshma Srilakshmi, R., Sriram, D. (2017) Lead identification and optimization of bacterial glutamate racemase inhibitors. Bioorganic & Medicinal Chemistry. 26(1):177-190
|
Marvadi, S.K., Krishna, V.S., Surineni, G., Srilakshmi Reshma, R., Sridhar, B., Sriram, D., Kantevari, S. (2020) Synthesis, in vitro, and in vivo (Zebra fish) antitubercular activity of 7,8-dihydroquinolin-5(6H)-ylidenehydrazinecarbothioamides. Bioorganic chemistry. 96:103626
|
|
Mohanty, S., Jagannathan, L., Ganguli, G., Padhi, A., Roy, D., Alaridah, N., Saha, P., Nongthomba, U., Godaly, G., Kumar, G.R., Banerjee, S., Sonawane, A. (2015) A mycobacterial phosphoribosyltransferase promotes bacillary survival by inhibiting oxidative stress and autophagy pathways in macrophages and zebrafish. The Journal of biological chemistry. 290(21):13321-43
|
Moreira, J.D., Koch, B.E.V., van Veen, S., Walburg, K.V., Vrieling, F., Mara Pinto Dabés Guimarães, T., Meijer, A.H., Spaink, H.P., Ottenhoff, T.H.M., Haks, M.C., Heemskerk, M.T. (2020) Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish. Frontiers in immunology. 11:36
|
|
Myllymäki, H., Niskanen, M., Oksanen, K.E., Sherwood, E., Ahava, M., Parikka, M., Rämet, M. (2017) Identification of novel antigen candidates for a tuberculosis vaccine in the adult zebrafish (Danio rerio). PLoS One. 12:e0181942
|
Ng, P.C.I., Chan, J.Y.W., Leung, R.K.K., Li, J., Ren, Z., Chan, A.W.H., Xu, Y., Lee, S.S., Wang, R., Ji, X., Zheng, J., Chan, D.P.C., Yew, W.W., Lee, S.M.Y. (2020) Role of oxidative stress in clofazimine-induced cardiac dysfunction in a zebrafish model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 132:110749
|
Ni, J., Wang, H., Wei, X., Shen, K., Sha, Y., Dong, Y., Shu, Y., Wan, X., Cheng, J., Wang, F., Liu, Y. (2020) Isoniazid causes heart looping disorder in zebrafish embryos by the induction of oxidative stress. BMC pharmacology & toxicology. 21:22
|
|
Ojanen, M.J.T., Uusi-Mäkelä, M.I.E., Harjula, S.E., Saralahti, A.K., Oksanen, K.E., Kähkönen, N., Määttä, J.A.E., Hytönen, V.P., Pesu, M., Rämet, M. (2019) Intelectin 3 is dispensable for resistance against a mycobacterial infection in zebrafish (Danio rerio). Scientific Reports. 9:995
|
Oksanen, K.E., Halfpenny, N.J., Sherwood, E., Harjula, S.K., Hammarén, M.M., Ahava, M.J., Pajula, E.T., Lahtinen, M.J., Parikka, M., and Rämet, M. (2013) An adult zebrafish model for preclinical tuberculosis vaccine development. Vaccine. 31(45):5202-9
|
Ordas, A., Raterink, R.J., Jansen, H.J., Cunningham, F., Wiweger, M.I., Jong-Raadsen, S., Bates, R.H., Barros, D., Meijer, A.H., Vreeken, R.J., Ballell-Pages, L., Dirks, R.P., Hankemeier, T., Spaink, H.P. (2015) Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen. Antimicrobial Agents and Chemotherapy. 59(2):753-62
|
Pacheco, I., Contreras, M., Villar, M., Risalde, M.A., Alberdi, P., Cabezas-Cruz, A., Gortázar, C., de la Fuente, J. (2020) Vaccination with Alpha-Gal Protects Against Mycobacterial Infection in the Zebrafish Model of Tuberculosis. Vaccines. 8(2):
|
|
Pagán, A.J., Yang, C.T., Cameron, J., Swaim, L.E., Ellett, F., Lieschke, G.J., Ramakrishnan, L. (2015) Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment. Cell Host & Microbe. 18:15-26
|
Parikka, M., Hammarén, M.M., Harjula, S.K., Halfpenny, N.J., Oksanen, K.E., Lahtinen, M.J., Pajula, E.T., Iivanainen, A., Pesu, M., and Rämet, M. (2012) Mycobacterium marinum Causes a Latent Infection that Can Be Reactivated by Gamma Irradiation in Adult Zebrafish. PLoS pathogens. 8(9):e1002944
|
Phan, T.H., van Leeuwen, L.M., Kuijl, C., Ummels, R., van Stempvoort, G., Rubio-Canalejas, A., Piersma, S.R., Jiménez, C.R., van der Sar, A.M., Houben, E.N.G., Bitter, W. (2018) EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF. PLoS pathogens. 14:e1007247
|
Puyskens, A., Stinn, A., van der Vaart, M., Kreuchwig, A., Protze, J., Pei, G., Klemm, M., Guhlich-Bornhof, U., Hurwitz, R., Krishnamoorthy, G., Schaaf, M., Krause, G., Meijer, A.H., Kaufmann, S.H.E., Moura-Alves, P. (2019) Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes. Cell Host & Microbe. 27(2):238-248.e7
|
Spain, M., Wong, J.K., Nagalingam, G., Batten, J.M., Hortle, E., Oehlers, S., Jiang, X.F., Murage, H.E., Orford, J.T., Crisologo, P., Triccas, J.A., Rutledge, P.J., Todd, M.H. (2018) Anti-Tubercular bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and In Vivo Studies. Journal of medicinal chemistry. 61(8):3595-3608
|
|
Su, H., Peng, B., Zhang, Z., Liu, Z., Zhang, Z. (2019) The Mycobacterium tuberculosis glycoprotein Rv1016c protein inhibits dendritic cell maturation, and impairs Th1 /Th17 responses during mycobacteria infection. Molecular immunology. 109:58-70
|
Tong, J., Meng, L., Wang, X., Liu, L., Lyu, L., Wang, C., Li, Y., Gao, Q., Yang, C., Niu, C. (2016) The FBPase Encoding Gene glpX Is Required for Gluconeogenesis, Bacterial Proliferation and Division In Vivo of Mycobacterium marinum. PLoS One. 11:e0156663
|
Tran, W., Kusay, A.S., Hawkins, P.M.E., Cheung, C.Y., Nagalingam, G., Pujari, V., Ford, D.J., Stoye, A., Ochoa, J.L., Audette, R.E., Hortle, E., Oehlers, S.H., Charman, S.A., Linington, R.G., Rubin, E.J., Dowson, C.G., Roper, D.I., Crick, D.C., Balle, T., Cook, G.M., Britton, W.J., Payne, R.J. (2021) Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors. Journal of medicinal chemistry. 64(23):17326-17345
|
van der Niet, S., van Zon, M., de Punder, K., Grootemaat, A., Rutten, S., Moorlag, S.J.C.F.M., Houben, D., van der Sar, A.M., Bitter, W., Brosch, R., Hernandez Pando, R., Pena, M.T., Peters, P.J., Reits, E.A., Mayer-Barber, K.D., van der Wel, N.N. (2021) IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo. mSphere. 6(3):
|
van Wijk, R.C., Hu, W., Dijkema, S.M., van den Berg, D.J., Liu, J., Bahi, R., Verbeek, F.J., Simonsson, U.S.H., Spaink, H.P., van der Graaf, P.H., Krekels, E.H.J. (2020) Anti-tuberculosis effect of isoniazid scales accurately from zebrafish to humans. British journal of pharmacology. 177(24):5518-5533
|
Wu, X., Wu, Y., Zheng, R., Tang, F., Qin, L., Lai, D., Zhang, L., Chen, L., Yan, B., Yang, H., Wang, Y., Li, F., Zhang, J., Wang, F., Wang, L., Cao, Y., Ma, M., Liu, Z., Chen, J., Huang, X., Wang, J., Jin, R., Wang, P., Sun, Q., Sha, W., Lyu, L., Moura-Alves, P., Dorhoi, A., Pei, G., Zhang, P., Chen, J., Gao, S., Randow, F., Zeng, G., Chen, C., Ye, X.S., Kaufmann, S.H.E., Liu, H., Ge, B. (2021) Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection. EMBO reports. 22(7):e51678
|
Zhang, Q., Wang, D., Jiang, G., Liu, W., Deng, Q., Li, X., Qian, W., Ouellet, H., Sun, J. (2016) EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5. Scientific Reports. 6:32618
|
Zhang, R., Varela, M., Forn-Cuní, G., Torraca, V., van der Vaart, M., Meijer, A.H. (2020) Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages. Cell Death & Disease. 11:277
|