ZFIN is now using GRCz12tu for Genomic Data
Gene
bmp4
- ID
- ZDB-GENE-980528-2059
- Name
- bone morphogenetic protein 4
- Symbol
- bmp4 Nomenclature History
- Previous Names
-
- bmp-4
- zbmp-4
- etID309887.17 (1)
- zgc:100779
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cytokine activity. Acts upstream of or within several processes, including determination of bilateral symmetry; embryonic morphogenesis; and embryonic organ development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; fin; head; mesoderm; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 326 figures from 250 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu728 (27 images)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| orofacial cleft 11 | Alliance | Orofacial cleft 11 | 600625 |
| syndromic microphthalmia 6 | Alliance | Microphthalmia, syndromic 6 | 607932 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Domain | IPR047833 | Bone morphogenetic protein 4, TGF-beta-like domain |
| Family | IPR015615 | Transforming growth factor-beta-like |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
Domain Details Per Protein
| Protein | Additional Resources | Length | Bone morphogenetic protein 4, TGF-beta-like domain | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-like |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:O57574 | InterPro | 400 | ||||||
| UniProtKB:A0AC58HM40 | InterPro | 400 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers