ZFIN is now using GRCz12tu for Genomic Data
Gene
cd40lg
- ID
- ZDB-GENE-100727-1
- Name
- CD40 ligand
- Symbol
- cd40lg Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cytokine activity. Predicted to be involved in cell surface receptor signaling pathway; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be active in extracellular region. Is expressed in gill; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; Kawasaki disease; antiphospholipid syndrome; combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| CD40 ligand deficiency | Alliance | Immunodeficiency, X-linked, with hyper-IgM | 308230 |
| X-linked hyper IgM syndrome | Alliance | Immunodeficiency, X-linked, with hyper-IgM | 308230 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Tumour necrosis factor, conserved site | Tumour necrosis factor domain | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:B8YI05 | InterPro | 260 | |||
| UniProtKB:A0AC58H726 | InterPro | 261 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cd40lg-201
(1)
|
Ensembl | 1,791 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cd40lg | IgG | Rabbit |
|
2 |
Plasmids
No data available
- Genome Browsers