Gene
cd40lg
- ID
- ZDB-GENE-100727-1
- Name
- CD40 ligand
- Symbol
- cd40lg Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables CD40 receptor binding activity. Acts upstream of or within positive regulation of immunoglobulin production. Located in external side of plasma membrane. Is expressed in gill; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa42412 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| CD40 ligand deficiency | Alliance | Immunodeficiency, X-linked, with hyper-IgM | 308230 |
| X-linked hyper IgM syndrome | Alliance | Immunodeficiency, X-linked, with hyper-IgM | 308230 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Tumour necrosis factor, conserved site | Tumour necrosis factor domain | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:B8YI05 | InterPro | 260 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cd40lg-201
(1)
|
Ensembl | 1,791 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cd40lg | IgG | Rabbit |
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-127L15 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001144809 (1) | 1804 nt | ||
| Genomic | GenBank:AL929434 (2) | 178948 nt | ||
| Polypeptide | UniProtKB:B8YI05 (1) | 260 aa |
- Hong, Y., Hu, C.B., Bai, J., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2023) Essential role of an ERV-derived Env38 protein in adaptive humoral immunity against an exogenous SVCV infection in a zebrafish model. PLoS pathogens. 19:e1011222e1011222
- Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
- Shao, T., Ji, J.F., Zheng, J.Y., Li, C., Zhu, L.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 208(12):2686-2701
- Su, N., Hu, C.B., Shao, T., Jin, C.Y., Li, H., Ji, J.F., Qin, L.L., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2021) Functional role of CD40 and CD154 costimulatory signals in IgZ-mediated immunity against bacterial infection. Fish and shellfish Immunology reports. 2:100038100038
- Qin, J., Ru, S., Wang, W., Hao, L., Ru, Y., Wang, J., Zhang, X. (2020) Long-term bisphenol S exposure aggravates non-alcoholic fatty liver by regulating lipid metabolism and inducing endoplasmic reticulum stress response with activation of unfolded protein response in male zebrafish. Environmental pollution (Barking, Essex : 1987). 263:114535
- Shi, W., Shao, T., Li, J.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2019) BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 203(9):2425-2442
- Liu, G.P., Xiang, L.X., Shao, T., Lin, A.F., Shao, J.Z. (2018) Stimulatory function of peroxiredoxin 1 in activating adaptive humoral immunity in a zebrafish model. Developmental and comparative immunology. 84:353-360
- Wan, F., Hu, C.B., Ma, J.X., Gao, K., Xiang, L.X., Shao, J.Z. (2017) Characterization of γδ T Cells from Zebrafish Provides Insights into Their Important Role in Adaptive Humoral Immunity. Frontiers in immunology. 7:675
- Xu, X.G., Hu, J.F., Ma, J.X., Nie, L., Shao, T., Xiang, L.X., Shao, J.Z. (2016) Essential Roles of TIM-1 and TIM-4 Homologs in Adaptive Humoral Immunity in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 196(4):1686-99
- Biswas, G., Kinoshita, S., Kono, T., Hikima, J.I., Sakai, M. (2015) Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Marine genomics. 22:25-36
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