Gene

cd40lg

ID
ZDB-GENE-100727-1
Name
CD40 ligand
Symbol
cd40lg Nomenclature History
Previous Names
  • cd154 (1)
  • TNFSF5 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Exhibits CD40 receptor binding activity. Involved in positive regulation of immunoglobulin production. Localizes to external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune hypersensitivity disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Is expressed in gill; integument; liver; and pleuroperitoneal region. Orthologous to human CD40LG (CD40 ligand).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cd40lg Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
CD40 ligand deficiency Alliance Immunodeficiency, X-linked, with hyper-IgM 308230
X-linked hyper IgM syndrome Alliance Immunodeficiency, X-linked, with hyper-IgM 308230
Associated With cd40lg Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR021184 Tumour necrosis factor, conserved site
Domain IPR006052 Tumour necrosis factor domain
Homologous_superfamily IPR008983 Tumour necrosis factor-like domain superfamily
Domain Details Per Protein
Protein Length Tumour necrosis factor, conserved site Tumour necrosis factor domain Tumour necrosis factor-like domain superfamily
UniProtKB:B8YI05 260
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cd40lg IgG Rabbit
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations