ZFIN is now using GRCz12tu for Genomic Data
Gene
tgfbi
- ID
- ZDB-GENE-030131-73
- Name
- transforming growth factor, beta-induced
- Symbol
- tgfbi Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within cellular response to xenobiotic stimulus and muscle cell development. Predicted to be non-collagenous component of basement membrane. Predicted to be active in extracellular matrix. Is expressed in several structures, including head mesenchyme; liver; neural crest cell; paraxial mesoderm; and splanchnocranium. Human ortholog(s) of this gene implicated in corneal dystrophy (multiple). Orthologous to human TGFBI (transforming growth factor beta induced).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6903641 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Kim et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| epithelial basement membrane dystrophy | Alliance | Corneal dystrophy, epithelial basement membrane | 121820 |
| granular corneal dystrophy 1 | Alliance | Corneal dystrophy, Groenouw type I | 121900 |
| granular corneal dystrophy 2 | Alliance | Corneal dystrophy, Avellino type | 607541 |
| lattice corneal dystrophy | Alliance | Corneal dystrophy, lattice type I | 122200 |
| Reis-Bucklers corneal dystrophy | Alliance | Corneal dystrophy, Reis-Bucklers type | 608470 |
| Thiel-Behnke corneal dystrophy | Alliance | Corneal dystrophy, Thiel-Behnke type | 602082 |
| Corneal dystrophy, lattice type IIIA | 608471 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cell adhesion and biosynthesis-related protein | EMI domain | FAS1 domain | FAS1 domain superfamily | TGF beta-induced protein/periostin |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T1R2 | InterPro | 677 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers