- Title
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Aging-associated sinus arrest and sick sinus syndrome in adult zebrafish
- Authors
- Yan, J., Li, H., Bu, H., Jiao, K., Zhang, A.X., Le, T., Cao, H., Li, Y., Ding, Y., Xu, X.
- Source
- Full text @ PLoS One
Quality of electrocardiography (ECG) signals is improved by optimizing location of the probes and microsurgery. A, Different ECG waveform with distinct P, R, S, and T waves when probes were at a different location relative to the heart (red dots). We recommend aligning the positive probe to the heart (ii), whereby the ECG waveform is similar to that in humans. B, Microsurgery was conducted to open the pericardium sac and thus eliminate noise and enhance amplitude of the waveforms by about 10-fold. C, Change in heart rate with surgery. bpm indicates beats per minute; WT, wild-type. |
ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions. PHENOTYPE:
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Cardiac function remains unchanged between wild-type fish with (WTSA) and without (WTNormal) sinus arrest. A, Representative B mode echocardiogram of a zebrafish heart at end-diastole (top left) and end-systole (top right) and pulsed-wave Doppler images for quantification of E wave, A wave, IVCT, ET, and IVRT. B-G, Quantification of cardiac function indices between WTNormal and WTSA siblings. *P < .05 (Student t test). A indicates peak velocity of late ventricular filling; BW, body weight; E, peak velocity of early ventricular filling; EDV, end-diastolic volume; EF, ejection fraction; ESV, end-systolic volume; ET, ejection time; IVCT, isovolumic contraction time; IVRT, isovolumic relaxation time; LAX, long axis; MPI, myocardial performance index; ns, not significant; SAX, short axis; WTSA, wild-type fish with SA; WTNormal, wild-type fish without SA. |