Cardiac function remains unchanged between wild-type fish with (WTSA) and without (WTNormal) sinus arrest.
A, Representative B mode echocardiogram of a zebrafish heart at end-diastole (top left) and end-systole (top right) and pulsed-wave Doppler images for quantification of E wave, A wave, IVCT, ET, and IVRT. B-G, Quantification of cardiac function indices between WTNormal and WTSA siblings. *P < .05 (Student t test). A indicates peak velocity of late ventricular filling; BW, body weight; E, peak velocity of early ventricular filling; EDV, end-diastolic volume; EF, ejection fraction; ESV, end-systolic volume; ET, ejection time; IVCT, isovolumic contraction time; IVRT, isovolumic relaxation time; LAX, long axis; MPI, myocardial performance index; ns, not significant; SAX, short axis; WTSA, wild-type fish with SA; WTNormal, wild-type fish without SA.