Gene
tecta
- ID
- ZDB-GENE-110411-120
- Name
- tectorin alpha
- Symbol
- tecta Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have extracellular matrix structural constituent. Involved in otolith tethering. Predicted to localize to collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 12; autosomal recessive nonsyndromic deafness 21; and sensorineural hearing loss. Is expressed in inner ear and otic vesicle. Orthologous to human TECTA (tectorin alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 12 | Alliance | Deafness, autosomal dominant 8/12 | 601543 |
| autosomal recessive nonsyndromic deafness 21 | Alliance | Deafness, autosomal recessive 21 | 603629 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001007 | VWFC domain |
| Domain | IPR001507 | Zona pellucida domain |
| Domain | IPR001846 | von Willebrand factor, type D domain |
| Domain | IPR002919 | Trypsin Inhibitor-like, cysteine rich domain |
| Domain | IPR003886 | NIDO domain |
| Domain | IPR014853 | Uncharacterised domain, cysteine-rich |
| Domain | IPR025615 | TILa domain |
| Family | IPR033026 | Alpha-tectorin |
| Homologous_superfamily | IPR036084 | Serine protease inhibitor-like superfamily |
| Homologous_superfamily | IPR042235 | Zona pellucida, ZP-C domain |
Domain Details Per Protein
| Protein | Length | Alpha-tectorin | EGF-like domain | NIDO domain | Serine protease inhibitor-like superfamily | TILa domain | Trypsin Inhibitor-like, cysteine rich domain | Uncharacterised domain, cysteine-rich | von Willebrand factor, type D domain | VWFC domain | Zona pellucida domain | Zona pellucida, ZP-C domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QK57
|
2201 | |||||||||||
|
UniProtKB:F8W4F4
|
921 |
Interactions and Pathways
No data available
Plasmids
No data available