Gene
tecta
- ID
- ZDB-GENE-110411-120
- Name
- tectorin alpha
- Symbol
- tecta Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Acts upstream of or within otolith tethering. Predicted to be located in extracellular region and plasma membrane. Is expressed in inner ear and otic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 12; autosomal recessive nonsyndromic deafness 21; and sensorineural hearing loss. Orthologous to human TECTA (tectorin alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant nonsyndromic deafness 12 | Alliance | Deafness, autosomal dominant 8/12 | 601543 |
autosomal recessive nonsyndromic deafness 21 | Alliance | Deafness, autosomal recessive 21 | 603629 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000742 | EGF-like domain |
Domain | IPR001007 | VWFC domain |
Domain | IPR001507 | Zona pellucida domain |
Domain | IPR001846 | von Willebrand factor, type D domain |
Domain | IPR002919 | Trypsin Inhibitor-like, cysteine rich domain |
Domain | IPR003886 | NIDO domain |
Domain | IPR014853 | VWF/SSPO/Zonadhesin-like, cysteine-rich domain |
Domain | IPR025615 | TILa domain |
Domain | IPR055355 | ZP-C domain |
Family | IPR052749 | Alpha-tectorin |
Homologous_superfamily | IPR036084 | Serine protease inhibitor-like superfamily |
Homologous_superfamily | IPR042235 | Zona pellucida, ZP-C domain |
Domain Details Per Protein
Protein | Additional Resources | Length | Alpha-tectorin | EGF-like domain | NIDO domain | Serine protease inhibitor-like superfamily | TILa domain | Trypsin Inhibitor-like, cysteine rich domain | von Willebrand factor, type D domain | VWFC domain | VWF/SSPO/Zonadhesin-like, cysteine-rich domain | Zona pellucida domain | Zona pellucida, ZP-C domain | ZP-C domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M6YZF6 | InterPro | 1803 | ||||||||||||
UniProtKB:A0A8M3ASW3 | InterPro | 2201 |
Interactions and Pathways
No data available
Plasmids
No data available