Gene

tecta

ID

ZDB-GENE-110411-120

Name

tectorin alpha

Symbol

tecta Nomenclature History

Previous Names

rst (1)
rolling stones (1)
si:ch211-122g23.2

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Acts upstream of or within otolith tethering. Predicted to be located in extracellular region and plasma membrane. Is expressed in inner ear and otic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 12; autosomal recessive nonsyndromic deafness 21; and sensorineural hearing loss. Orthologous to human TECTA (tectorin alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tecta Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 12	Alliance	Deafness, autosomal dominant 8/12	601543
autosomal recessive nonsyndromic deafness 21	Alliance	Deafness, autosomal recessive 21	603629

Associated With tecta Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR001007	VWFC domain
Domain	IPR001507	Zona pellucida domain
Domain	IPR001846	von Willebrand factor, type D domain
Domain	IPR002919	Trypsin Inhibitor-like, cysteine rich domain
Domain	IPR003886	NIDO domain
Domain	IPR014853	VWF/SSPO/Zonadhesin-like, cysteine-rich domain
Domain	IPR025615	TILa domain
Domain	IPR055355	ZP-C domain
Family	IPR052749	Alpha-tectorin
Homologous_superfamily	IPR036084	Serine protease inhibitor-like superfamily
Homologous_superfamily	IPR042235	Zona pellucida, ZP-C domain

Domain Details Per Protein

Protein	Additional Resources	Length	Alpha-tectorin	EGF-like domain	NIDO domain	Serine protease inhibitor-like superfamily	TILa domain	Trypsin Inhibitor-like, cysteine rich domain	von Willebrand factor, type D domain	VWFC domain	VWF/SSPO/Zonadhesin-like, cysteine-rich domain	Zona pellucida domain	Zona pellucida, ZP-C domain	ZP-C domain
UniProtKB:A0A8M6YZF6	InterPro	1803
UniProtKB:A0A8M3ASW3	InterPro	2201

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tecta-201 (1) Ensembl	Ensembl		6,606 nt	Select Tool ZFIN BLAST
mRNA	tecta-202 (1) Ensembl	Ensembl		3,118 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tecta	polyclonal	tecta		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations