Gene

tecta

ID
ZDB-GENE-110411-120
Name
tectorin alpha
Symbol
tecta Nomenclature History
Previous Names
  • rst (1)
  • rolling stones (1)
  • si:ch211-122g23.2
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have extracellular matrix structural constituent. Involved in otolith tethering. Predicted to localize to collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 12; autosomal recessive nonsyndromic deafness 21; and sensorineural hearing loss. Is expressed in inner ear and otic vesicle. Orthologous to human TECTA (tectorin alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tecta Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 12 Alliance Deafness, autosomal dominant 8/12 601543
autosomal recessive nonsyndromic deafness 21 Alliance Deafness, autosomal recessive 21 603629
Associated With tecta Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR001007 VWFC domain
Domain IPR001507 Zona pellucida domain
Domain IPR001846 von Willebrand factor, type D domain
Domain IPR002919 Trypsin Inhibitor-like, cysteine rich domain
Domain IPR003886 NIDO domain
Domain IPR014853 Uncharacterised domain, cysteine-rich
Domain IPR025615 TILa domain
Family IPR033026 Alpha-tectorin
Homologous_superfamily IPR036084 Serine protease inhibitor-like superfamily
Homologous_superfamily IPR042235 Zona pellucida, ZP-C domain
Domain Details Per Protein
Protein Length Alpha-tectorin EGF-like domain NIDO domain Serine protease inhibitor-like superfamily TILa domain Trypsin Inhibitor-like, cysteine rich domain Uncharacterised domain, cysteine-rich von Willebrand factor, type D domain VWFC domain Zona pellucida domain Zona pellucida, ZP-C domain
UniProtKB:F8W4F4 921
UniProtKB:F1QK57 2201
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tecta polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations