Gene

npl

ID
ZDB-GENE-030131-926
Name
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
Symbol
npl Nomenclature History
Previous Names
  • wu:fb53b06
  • zgc:76930
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have N-acetylneuraminate lyase activity. Predicted to be involved in N-acetylneuraminate catabolic process and carbohydrate metabolic process. Predicted to localize to cytoplasm. Used to study myopathy. Is expressed in several structures, including fin bud; gut; muscle; vein; and yolk syncytial layer. Orthologous to human NPL (N-acetylneuraminate pyruvate lyase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Wen et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With npl Human Ortholog
No data available
Associated With npl Via Experimental Models
Human Disease Fish Conditions Citations
myopathy WT + MO1-npl control Wen et al., 2018
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020624 Schiff base-forming aldolase, conserved site
Family IPR002220 DapA-like
Homologous_superfamily IPR013785 Aldolase-type TIM barrel
Domain Details Per Protein
Protein Length Aldolase-type TIM barrel DapA-like Schiff base-forming aldolase, conserved site
UniProtKB:Q6NYR8 307
UniProtKB:A9C3P6 307
UniProtKB:A9JTB1 307
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations