PUBLICATION
LIM domains: multiple roles as adapters and functional modifiers in protein interactions
- Authors
- Dawid, I.B., Breen, J.J., and Toyama, R.
- ID
- ZDB-PUB-990604-11
- Date
- 1998
- Source
- Trends in genetics : TIG 14(4): 156-162 (Review)
- Registered Authors
- Breen, Joe, Dawid, Igor B., Toyama, Reiko
- Keywords
- none
- MeSH Terms
-
- Animals
- Homeodomain Proteins/genetics
- Homeodomain Proteins/physiology*
- Humans
- PubMed
- 9594664 Full text @ Trends Genet.
Citation
Dawid, I.B., Breen, J.J., and Toyama, R. (1998) LIM domains: multiple roles as adapters and functional modifiers in protein interactions. Trends in genetics : TIG. 14(4):156-162.
Abstract
The LIM domain is a specialized double-zinc finger motif found in a variety of proteins, in association with domains of divergent functions or forming proteins composed primarily of LIM domains. LIM domains interact specifically with other LIM domains and with many different protein domains. LIM domains are thought to function as protein interaction modules, mediating specific contacts between members of functional complexes and modulating the activity of some of the constituent proteins. Nucleic acid binding by LIM domains, while suggested by structural considerations, remains an unproven possibility. LIM-domain proteins can be nuclear, cytoplasmic, or can shuttle between compartments. Several important LIM proteins are associated with the cytoskeleton, having a role in adhesion-plaque and actin-microfilament organization. Among nuclear LIM proteins, the LIM homeodomain proteins form a major subfamily with important functions in cell lineage determination and pattern formation during animal development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping