PUBLICATION
Left-right development in Xenopus and zebrafish
- Authors
- Yost, H.J.
- ID
- ZDB-PUB-990108-13
- Date
- 1998
- Source
- Seminars in cell & developmental biology 9: 61-66 (Journal)
- Registered Authors
- Yost, H. Joseph
- Keywords
- none
- MeSH Terms
-
- Animals
- Biological Evolution
- Body Patterning*
- Cytoskeleton/physiology
- Twins, Conjoined/embryology
- Xenopus/embryology*
- Zebrafish/embryology*
- PubMed
- 9572115 Full text @ Sem. Cell Dev. Biol.
Citation
Yost, H.J. (1998) Left-right development in Xenopus and zebrafish. Seminars in cell & developmental biology. 9:61-66.
Abstract
One of the most striking features of the vertebrate body plan is that most exterior structures are bilaterally symmetric while many interior structures are left-right asymmetric. Left-right asymmetries are displayed in the heart, the circulatory, digestive and respiratory systems and in the central nervous system. A fundamental question in the study of all patterning events, including left-right axis formation, is how does asymmetry arise from apparent symmetry. A second important question that is perhaps unique to the study of left-right development, is how does the left-right axis align with the asymmetries that develop along the orthogonal axes; dorsal-ventral and anterior-posterior. Recent experiments in Xenopus laevis and zebrafish address both of these questions and have identified signaling molecules and interactions with midline cells that regulate left-right development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping