ZFIN Person: Yost, H. Joseph

ZFIN ID: ZDB-PERS-960805-628

Yost, H. Joseph

Email:	jyost@genetics.utah.edu
URL:	http://yost.genetics.utah.edu/
Affiliation:	Yost Lab
Address:	University of Utah Molecular Medicine Program Eccles Institute of Human Genetics Bldg. 533, Room 3160, 15 North 2030 East Salt Lake City, UT 84112-5330
Country:	United States
Phone:	1-801-585-6110
Fax:	1-801-585-5470
ORCID ID:	0000-0003-2961-5669

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Eisa-Beygi, S., Hu, M.M., Kumar, S.N., Jeffery, B.E., Collery, R.F., Vo, N.J., Lamichanne, B.S., Yost, H.J., Veldman, M.B., Link, B.A. (2023) Mesenchymal Stromal Cells Facilitate Tip Cell Fusion Downstream of BMP (Bone Morphogenic Protein)-Mediated Venous Angiogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology. 43(7):e231-e237

Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):

Yates, J.D., Russell, R.C., Barton, N.J., Yost, H.J., Hill, J.T. (2021) A simple and rapid method for enzymatic synthesis of CRISPR-Cas9 sgRNA libraries. Nucleic acids research. 49(22):e131

Parvez, S., Herdman, C., Beerens, M., Chakraborti, K., Harmer, Z.P., Yeh, J.J., MacRae, C.A., Yost, H.J., Peterson, R.T. (2021) MIC-Drop: A platform for large-scale in vivo CRISPR screens. Science (New York, N.Y.). 373(6559):1146-1151

Edwards, J.J., Rouillard, A.D., Fernandez, N.F., Wang, Z., Lachmann, A., Shankaran, S.S., Bisgrove, B.W., Demarest, B., Turan, N., Srivastava, D., Bernstein, D., Deanfield, J., Giardini, A., Porter, G., Kim, R., Roberts, A.E., Newburger, J.W., Goldmuntz, E., Brueckner, M., Lifton, R.P., Seidman, C.E., Chung, W.K., Tristani-Firouzi, M., Yost, H.J., Ma'ayan, A., Gelb, B.D. (2020) Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. JACC. Basic to translational science. 5:376-386

Capasso, T.L., Li, B., Volek, H.J., Khalid, W., Rochon, E.R., Anbalagan, A., Herdman, C., Yost, H.J., Villanueva, F.S., Kim, K., Roman, B.L. (2019) BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance. Angiogenesis. 23(2):203-220

Jurynec, M.J., Bai, X., Bisgrove, B.W., Jackson, H., Nechiporuk, A., Palu, R.A.S., Grunwald, H.A., Su, Y.C., Hoshijima, K., Yost, H.J., Zon, L.I., Grunwald, D.J. (2019) The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development (Cambridge, England). 146(24):

Serrano, M.L.A., Demarest, B.L., Tone-Pah-Hote, T., Tristani-Firouzi, M., Yost, H.J. (2019) Inhibition of Notch signaling rescues cardiovascular development in Kabuki Syndrome. PLoS Biology. 17:e3000087

Abdul-Wajid, S., Demarest, B.L., Yost, H.J. (2018) Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish. Nature communications. 9:4603

Karanth, S., Adams, J.D., Serrano, M.L.A., Quittner-Strom, E.B., Simcox, J., Villanueva, C.J., Ozcan, L., Holland, W.L., Yost, H.J., Vella, A., Schlegel, A. (2018) A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose. Cell Reports. 24:312-319

Bisgrove, B.W., Su, Y.C., Yost, H.J. (2017) Maternal Gdf3 is an obligatory cofactor in nodal signaling for embryonic axis formation in zebrafish. eLIFE. 6

Hill, J.T., Demarest, B., Smith, M., Gorsi, B., Yost, H.J. (2017) Heart morphogenesis gene regulatory networks revealed by temporal expression analysis. Development (Cambridge, England). 144(19):3487-3498

Shankaran, S.S., Dahlem, T.J., Bisgrove, B.W., Yost, H.J., Tristani-Firouzi, M. (2017) CRISPR/Cas9-Directed Gene Editing for the Generation of Loss-of-Function Mutants in High-Throughput Zebrafish F₀ Screens.. Current protocols in molecular biology. 119:31.9.1-31.9.22

Karanth, S., Zinkhan, E.K., Hill, J.T., Yost, H.J., Schlegel, A. (2016) FOXN3 Regulates Hepatic Glucose Utilization. Cell Reports. 15(12):2745-55

Poulain, F.E., Yost, H.J. (2015) Heparan sulfate proteoglycans: a sugar code for vertebrate development?. Development (Cambridge, England). 142:3456-67

Percival, S.M., Thomas, H.R., Amsterdam, A., Carroll, A.J., Lees, J.A., Yost, H.J., Parant, J.M. (2015) Variations in sister chromatid cohesion dysfunction in esco2 mutant zebrafish reflects the phenotypic diversity of Roberts Syndrome. Disease models & mechanisms. 8(8):941-55

Nash, D., Arrington, C.B., Kennedy, B.J., Yandell, M., Wu, W., Zhang, W., Ware, S., Jorde, L.B., Gruber, P.J., Yost, H.J., Bowles, N.E., Bleyl, S.B. (2015) Shared Segment Analysis and Next-Generation Sequencing Implicates the Retinoic Acid Signaling Pathway in Total Anomalous Pulmonary Venous Return (TAPVR). PLoS One. 10:e0131514

Samson, S.C., Ferrer, T., Jou, C.J., Sachse, F.B., Shankaran, S.S., Shaw, R.M., Chi, N.C., Tristani-Firouzi, M., and Yost, H.J. (2013) 3-OST-7 regulates BMP-dependent cardiac contraction. PLoS Biology. 11(12):e1001727

Peterson, A.G., Wang, X., and Yost, H. J. (2013) Dvr1 transfers left-right asymmetric signals from Kupffer's vesicle to lateral plate mesoderm in zebrafish. Developmental Biology. 382(1):198-208

Arrington, C.B., Peterson, A.G., and Yost, H.J. (2013) Sdc2 and Tbx16 regulate Fgf2-dependent epithelial cell morphogenesis in the ciliated organ of asymmetry. Development (Cambridge, England). 140(19):4102-4109

Neugebauer, J.M., Cadwallader, A.B., Amack, J.D., Bisgrove, B.W., and Yost, H.J. (2013) Differential roles for 3-OSTs in the regulation of cilia length and motility. Development (Cambridge, England). 140(18):3892-3902

Hill, J.T., Demarest, B.L., Bisgrove, B.W., Gorsi, B., Su, Y.C., and Yost, H.J. (2013) MMAPPR: Mutation Mapping Analysis Pipeline for Pooled RNA-seq. Genome research. 23(4):687-697

Tay, H.G., Schulze, S.K., Compagnon, J., Foley, F.C., Heisenberg, C.P., Yost, H.J., Abdelilah-Seyfried, S., and Amack, J.D. (2013) Lethal giant larvae 2 regulates development of the ciliated organ Kupffer's vesicle. Development (Cambridge, England). 140(7):1550-1559

Wang, G., Yost, H.J., and Amack, J.D. (2013) Analysis of Gene Function and Visualization of Cilia-Generated Fluid Flow in Kupffer's Vesicle. Journal of visualized experiments : JoVE. (73)

Jurisch-Yaksi, N., Rose, A.J., Lu, H., Raemaekers, T., Munck, S., Baatsen, P., Baert, V., Vermeire, W., Scales, S.J., Verleyen, D., Vandepoel, R., Tylzanowski, P., Yaksi, E., de Ravel, T., Yost, H.J., Froyen, G., Arrington, C.B., and Annaert, W. (2013) Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels. The Journal of cell biology. 200(6):709-720

Cadwalader, E.L., Condic, M.L., and Yost, H.J. (2012) 2-O-sulfotransferase regulates Wnt signaling, cell adhesion and cell cycle during zebrafish epiboly. Development (Cambridge, England). 139(7):1296-1305

Bisgrove, B.W., Makova, S., Yost, H.J., and Brueckner, M. (2012) RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow. Developmental Biology. 363(1):166-178

Wythe, J.D., Jurynec, M.J., Urness, L.D., Jones, C.A., Sabeh, M.K., Werdich, A.A., Sato, M., Yost, H.J., Grunwald, D.J., MacRae, C.A., and Li, D.Y. (2011) Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. Disease models & mechanisms. 4(5):607-21

Wang, G., Cadwallader, A.B., Jang, D.S., Tsang, M., Yost, H.J., and Amack, J.D. (2011) The Rho kinase Rock2b establishes anteroposterior asymmetry of the ciliated Kupffer's vesicle in zebrafish. Development (Cambridge, England). 138(1):45-54

Parant, J.M., George, S.A., Holden, J.A., and Yost, H.J. (2010) Genetic modeling of Li-Fraumeni syndrome in zebrafish. Disease models & mechanisms. 3(1-2):45-56

Parant, J.M., George, S.A., Pryor, R., Wittwer, C.T., and Yost, H.J. (2009) A rapid and efficient method of genotyping zebrafish mutants. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(12):3168-3174

Arrington, C.B., and Yost, H.J. (2009) Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo. Development (Cambridge, England). 136(18):3143-3152

Neugebauer, J.M., Amack, J.D., Peterson, A.G., Bisgrove, B.W., and Yost, H.J. (2009) FGF signalling during embryo development regulates cilia length in diverse epithelia. Nature. 458(7238):651-654

Wang, X., and Yost, H.J. (2008) Initiation and propagation of posterior to anterior (PA) waves in zebrafish left-right development. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(12):3640-3647

Wolman, M.A., Sittaramane, V., Essner, J.J., Yost, H.J., Chandrasekhar, A., and Halloran, M.C. (2008) Transient axonal glycoprotein-1 (TAG-1) and laminin-alpha1 regulate dynamic growth cone behaviors and initial axon direction in vivo. Neural Development. 3:6

Kwan, K.M., Fujimoto, E., Grabher, C., Mangum, B.D., Hardy, M.E., Campbell, D.S., Parant, J.M., Yost, H.J., Kanki, J.P., and Chien, C.B. (2007) The Tol2kit: A multisite gateway-based construction kit for Tol2 transposon transgenesis constructs. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(11):3088-3099

Amack, J.D., Wang, X., and Yost, H.J. (2007) Two T-box genes play independent and cooperative roles to regulate morphogenesis of ciliated Kupffer's vesicle in zebrafish. Developmental Biology. 310(2):196-210

Tsai, I.C., Amack, J.D., Gao, Z.H., Band, V., Yost, H.J., and Virshup, D.M. (2007) A Wnt-CKIε-Rap1 Pathway Regulates Gastrulation by Modulating SIPA1L1, a Rap GTPase Activating Protein. Developmental Cell. 12(3):335-347

Cadwallader, A.B., and Yost, H.J. (2007) Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish: III. 2-O-sulfotransferase and C5-epimerases. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(2):581-6

Takeuchi, J.K., Lickert, H., Bisgrove, B.W., Sun, X., Yamamoto, M., Chawengsaksophak, K., Hamada, H., Yost, H.J., Rossant, J., and Bruneau, B.G. (2007) Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. Proceedings of the National Academy of Sciences of the United States of America. 104(3):846-851

Cadwallader, A.B., and Yost, H.J. (2006) Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish: II. The 6-O-sulfotransferase family. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(12):3432-3437

Cadwallader, A.B., and Yost, H.J. (2006) Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish: I. The 3-O-sulfotransferase family. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(12):3423-3431

Sato, M., Tsai, H.J., and Yost, H.J. (2006) Semaphorin3D regulates invasion of cardiac neural crest cells into the primary heart field. Developmental Biology. 298(1):12-21

Nadauld, L.D., Chidester, S., Shelton, D.N., Rai, K., Broadbent, T., Sandoval, I.T., Peterson, P.W., Manos, E.J., Ireland, C.M., Yost, H.J., and Jones, D.A. (2006) Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development. Proceedings of the National Academy of Sciences of the United States of America. 103(36):13409-13414

Bisgrove, B.W., Snarr, B.S., Emrazian, A., and Yost, H.J. (2005) Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Developmental Biology. 287(2):274-288

Nadauld, L.D., Shelton, D.N., Chidester, S., Yost, H.J., and Jones, D.A. (2005) The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli. The Journal of biological chemistry. 280(34):30490-30495

Essner, J.J., Amack, J.D., Nyholm, M.K., Harris, E.B., and Yost, H.J. (2005) Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development (Cambridge, England). 132(6):1247-1260

Nadauld, L.D., Sandoval, I.T., Chidester, S., Yost, H.J., and Jones, D.A. (2004) Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation. The Journal of biological chemistry. 279(49):51581-51589

Amack, J.D., and Yost, H.J. (2004) The T box transcription factor no tail in ciliated cells controls zebrafish left-right asymmetry. Current biology : CB. 14(8):685-690

Liang, P., Jones, C.A., Bisgrove, B.W., Song, L., Glenn, S.T., Yost, H.J., and Gross, K.W. (2004) Genomic characterization and expression analysis of the first non-mammalian renin genes from zebrafish and pufferfish. Physiological Genomics. 16(3):314-322

Sato, M. and Yost, H.J. (2003) Cardiac neural crest contributes to cardiomyogenesis in zebrafish. Developmental Biology. 257(1):127-139

Kramer, K.L. and Yost, H.J. (2003) Heparan sulfate core proteins in cell-cell signaling. Annual review of genetics. 37:461-484

Bisgrove, B.W., Morelli, S.H., and Yost, H.J. (2003) Genetics of human laterality disorders: insights from vertebrate model systems. Annual review of genomics and human genetics. 4:1-32

Sato, M. and Yost, H.J. (2002) Do cardiac neural crest defects in zebrafish result in loss of cardiomyocytes?. Developmental Biology. 247(2):508

Prescott, S.M. and Yost, H.J. (2002) The COXes of Danio: from mechanistic model to experimental therapeutics. Proceedings of the National Academy of Sciences of the United States of America. 99(14):9084-9086

Essner, J.J., Vogan, K.J., Wagner, M.K., Tabin, C.J., Yost, H.J., and Brueckner, M. (2002) Conserved function for embryonic nodal cilia. Nature. 418(6893):37-38

Morgan, D., Goodship, J., Essner, J.J., Vogan, K.J., Turnpenny, L., Yost, J., Tabin, C.J., and Strachan, T. (2002) The left-right determinant inversin has highly conserved ankyrin repeat and IQ domains and interacts with calmodulin. Human genetics. 110(4):377-384

Kramer, K.L. and Yost, H.J. (2002) Cardiac left-right development: are the early steps conserved?. Cold Spring Harbor symposia on quantitative biology. 67:37-43

Hu, N., Yost, H.J., and Clark, E.B. (2001) Cardiac morphology and blood pressure in the adult zebrafish. The Anatomical record. 264(1):1-12

Bisgrove, B.W. and Yost, H.J. (2001) Classification of left-right patterning defects in zebrafish, mice, and humans. American journal of medical genetics. 101(4):315-323

Essner, J.J., Wang, X.H., Zhang, J., and Yost, H.J. (2001) The zebrafish inv gene is required for left-right brain and heart development. Developmental Biology. 235(1):181 (#44)

Hu, N., Clark, E.B., and Yost, H.J. (2001) Cardiac morphology and blood pressure in the adult zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A1231

Hu, N., Sedmera, D., Yost, H.J., and Clark, E.B. (2000) Structure and function of the developing zebrafish heart. The Anatomical record. 260(2):148-157

Bisgrove, B.W., Essner, J.J., Yost, H.J. (2000) Multiple pathways in the midline regulate concordant brain, heart and gut left-right asymmetry. Development (Cambridge, England). 127(16):3567-3579

Angelo, S., Lohr, J., Lee, K.H., Ticho, B.S., Breitbart, R.E., Hill, S., Yost, H.J., and Srivastava, D. (2000) Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development. Mechanisms of Development. 95(1-2):231-237

Essner, J.J., Branford, W.W., Zhang, J., and Yost, H.J. (2000) Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms. Development (Cambridge, England). 127(5):1081-1093

Lohr, J.L. and Yost, J. (2000) Vertebrate model systems in the study of early heart development: Xenopus and zebrafish. American journal of medical genetics. 97(4):248-257

Bisgrove, B.W., Essner, J.J., and Yost, H.J. (1999) Regulation of midline development by antagonism of lefty and nodal signaling. Development (Cambridge, England). 126(14):3253-3262

Ramsdell, A.F. and Yost, H.J. (1998) Molecular mechanisms of vertebrate left–right development. Trends in genetics : TIG. 14(11):459-465

Yost, H.J. (1998) The genetics of midline and cardiac laterality defects. Current opinion in cardiology. 13:185-189

Yost, H.J. (1998) Left-right development in Xenopus and zebrafish. Seminars in cell & developmental biology. 9:61-66

Danos, M.C. and Yost, H.J. (1996) Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus. Developmental Biology. 177:96-103

NON-ZEBRAFISH PUBLICATIONS