PUBLICATION

Hematopoietic mutations in the zebrafish

Authors
Weinstein, B.M., Schier, A.F., Abdelilah, S., Malicki, J., Solnica-Krezel, L., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Driever, W., and Fishman, M.C.
ID
ZDB-PUB-970210-26
Date
1996
Source
Development (Cambridge, England)   123: 303-309 (Journal)
Registered Authors
Abdelilah-Seyfried, Salim, Driever, Wolfgang, Fishman, Mark C., Malicki, Jarema, Schier, Alexander, Solnica-Krezel, Lilianna, Stainier, Didier, Stemple, Derek L., Weinstein, Brant M.
Keywords
primitive haematopoiesis; mutations; zebrafish
MeSH Terms
  • Animals
  • Blood Cells/pathology
  • Cell Differentiation/genetics
  • Embryo, Nonmammalian/blood supply
  • Hematopoiesis/genetics*
  • Hemolysis/genetics
  • Light/adverse effects
  • Mutation*
  • Zebrafish/blood
  • Zebrafish/embryology*
  • Zebrafish/genetics*
PubMed
9007250
Abstract
We have identified mutations that perturb the formation or differentiation of the first embryonic blood cells in the zebrafish embryo. These 'primitive' red blood cells originate in the intermediate cell mass of the trunk, a derivative of the dorsal lateral plate mesoderm. By transfusion of blood between embryos we demonstrate that this cohort of cells provides the embryo with all, or nearly all, of its blood cells until at least day 5 postfertilization. Larval lethal mutations generated by ENU mutagenesis affect different steps in the development of these cells. Some cause defects in precursor generation, others defects in differentiation, and others an increase in cellular photosensitivity.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes